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Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze

Storozheva ZI, Zakharova EI, Proshin AT (2021) Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze. Front Behav Neurosci 15:755373. doi: 10.3389/fnbeh.2021.755373

Objective: To examine the role of hippocampal and cortical ACh in the acquisition, consolidation, storage, retention and adaptive flexibility of new, recent and remote memory traces in spatial learning models.

Summary: The application of functional ablation or stimulation techniques is necessary. The approach used can be regarded as one of the possible ways of delineating temporal stages of spatial learning and could be applied in the studies of other signalling pathways.

Usage: Selective loss of septohippocampal and/or corticopetal cholinergic projections has been shown to cause attention deficit.

See: McGaughy J et al. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265, 1996. ; Lehmann O et al. A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG-saporin lesions of the nucleus basalis and/or the septal region. Eur J Neurosci 18(3):651-666, 2003.

Related Products: 192-IgG-SAP (Cat. #IT-01)