Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of […]
Cover Article: Dermorphin-SAP Kills MOR-Positive Cells Read More »
Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O (2001) Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Exp Neurol 170:36-47. doi: 10.1006/exnr.2001.7700 Summary: The authors used 192-Saporin (two 2.5-µg bilateral injections of 1 µg/µl; Cat. #IT-01) to eliminate cholinergic neurons in the rat, then
Martin JL, Sloviter RS (2001) Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of substance P. J Comp Neurol 436:127-152. doi: 10.1002/cne.1065 Usage: The authors used SSP-SAP (0.4 ng/10 nl; Cat. #IT-11). Related Products: SSP-SAP (Cat. #IT-11) Read the
Speth RC, Grove KL, Brownfield MS (2001) Immunohistochemical localization of AT-1A and AT-1B angiotensin II receptor subtypes in the rat adrenal. Endocrine Society ENDO 2001 – 83rd Annual Meeting of the Endocrine Society, Denver, Colorado. PMID: 909090 Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP)
Bennett VJ, Simmons MA (2001) Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation. BMC Chem Biol 1(1):1. doi: 10.1186/1472-6769-1-1 PMID: 11418083 Related Products: 192-IgG Mouse Monoclonal, Alexa488-labeled (Cat. #AB-N43FLA)
Ferreira G, Meurisse M, Tillet Y, Lévy F (2001) Distribution and co-localization of choline acetyltransferase and p75 neurotrophin receptors in the sheep basal forebrain: implications for the use of a specific cholinergic immunotoxin. Neuroscience 104(2):419-439. doi: 10.1016/s0306-4522(01)00075-6 PMID: 11377845 Summary: ME20.4 is a monoclonal antibody (Cat. #AB-N07) that has been shown to bind the p75
Sidebotham EL, Woodward MN, Kenny SE, Lloyd DA, Vaillant CR, Edgar DH (2001) Assessment of protein gene product 9.5 as a marker of neural crest-derived precursor cells in the developing enteric nervous system. Pediatr Surg Int 17:304-307. doi: 10.1007/s003830100599 PMID: 11409167 Related Products: Antibody to NGFR (Cat. #AB-N02)
Advanced Targeting Systems announces two new control molecules for use with immunotoxins. We now offer mouse IgG (Cat. #IT-18) or rat IgG (Cat. #IT-17) conjugated to saporin. These new controls are the same molecular weight, consist of similar, comparable materials — saporin and a rat or mouse IgG — and are synthesized with the same
Targeting Tools: Controls for Immunotoxins Read More »
Hartlage-Rübsamen M, Schliebs R (2001) Sequential upregulation of cell adhesion molecules in degenerating rat basal forebrain cholinergic neurons and in phagocytotic microglial cells. Brain Res 897(1-2):20-26. doi: 10.1016/s0006-8993(01)02093-5 Summary: Neurodegeneration, found in brain disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, is marked by a significant microglial response. This microglial activation is characterized by increased
Sarter M, Givens B, Bruno JP (2001) The cognitive neuroscience of sustained attention: where top-down meets bottom-up. Brain Res Brain Res Rev 35(2):146-160. doi: 10.1016/s0165-0173(01)00044-3 Summary: The findings from human and animal studies provide the basis for a relatively precise description of the neuronal circuits mediating sustained attention, and the dissociation between these circuits and
The cognitive neuroscience of sustained attention: where top-down meets bottom-up Read More »