Leung LS, Shen B, Ma J, Rajakumar N (2003) Cholinergic activity enhances hippocampal CA1 long-term potentiation during walking in rats. Neuroscience 2003 Abstracts 255.5. Society for Neuroscience, New Orleans, LA. Summary: Long-term potentiation (LTP) at the basal dendrites of CA1 pyramidal cells was induced by a single 200-Hz stimulation train (0.5-1 sec duration) in freely […]
Muir JL, Harrison FE (2003) H3 receptor antagonists modulate behaviour in a visual spatial attention task in rats with selective lesions of the nucleus basalis magnocellularis. Neuroscience 2003 Abstracts 296.7. Society for Neuroscience, New Orleans, LA. Summary: It is well known that the cholinergic system suffers a large amount of damage in Alzheimer’s Disease (AD).
Miller BT, Collins TJ (2003) Production and characterization of biotinylated gonadotropin-releasing hormone analogs conjugated to avidinylated saporin. Neuroscience 2003 Abstracts 325.15. Society for Neuroscience, New Orleans, LA. Summary: Saporin is a potent protein cytotoxin derived from the seeds of the plant Saponaria officinalis. Although unmodified saporin cannot permeate cellular membranes in appreciable amounts, this toxin
Kohls MD, Lappi DA (2003) Cholera toxin B-saporin cytotoxicity is correlated with the extent of GM1 expression on the cell surface. Neuroscience 2003 Abstracts 325.16. Society for Neuroscience, New Orleans, LA. Summary: Cholera toxin is composed of five B-subunits that mediate binding to the cell surface monosialoganglioside GM1, and one A-subunit that irreversibly activates adenylate
Awarded by ATS at Society for Neuroscience (SFN) New Orleans, Louisiana • November 8-12, 2003 Be sure to check out the cover article contributed by Dr. McGaughy in Targeting Trends newsletter (First Quarter, 2004). 425.4 CHOLINERGIC DEAFFERENTATION OF THE ENTORHINAL CORTEX IN RATS IMPAIRS ENCODING OF NOVEL BUT NOT FAMILIAR STIMULI IN A DELAYED NON-MATCH
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Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA (2003) Spinal neurons that possess the substance P receptor (SPR) modulate descending systems that control excitability of spinal nociceptive neurons. Neuroscience 2003 Abstracts 13.3. Society for Neuroscience, New Orleans, LA. Summary: We have recently shown that ablation of spinal SPR-expressing spinal neurons by intrathecal application of the
Herron P, Ismail NS (2003) Progressive effects of cholinergic depletion on cortical functional properties in the somatosensory cortex of rats. Neuroscience 2003 Abstracts 61.11. Society for Neuroscience, New Orleans, LA. Summary: The amount and duration of cholinergic depletion of basal forebrain input appear to be important for how significant the functional capacity of cortical neurons
Woods M, Whiteside G, Pearson M, Pomonis J, Turchin P, Walker K (2003) Ablation of a population of NK-1 expressing neurons in the dorsal horn of the spinal cord does not induce αβ sprouting into lamina II. Neuroscience 2003 Abstracts 64.11. Society for Neuroscience, New Orleans, LA. Summary: Peripheral nerve injury results in hyperalgesia and
Nolan BC, Freeman JH (2003) Purkinje cell depletion by ox7-saporin impairs eyeblink conditioned excitation and inhibition in rats. Neuroscience 2003 Abstracts 87.3. Society for Neuroscience, New Orleans, LA. Summary: The role of the cerebellar cortex in conditioned excitation has been demonstrated by studies that used lesions, inactivation, and electrical stimulation (e.g., Attwell, Rahman, & Yeo,