Author name: Kristen Hartman

192-IgG saporin lesions of the medial septum and vertical diagonal band impair cognitive flexibility.

Fletcher BR, Baxter MG, Rapp PR, Shapiro ML (2003) 192-IgG saporin lesions of the medial septum and vertical diagonal band impair cognitive flexibility. Neuroscience 2003 Abstracts 425.8. Society for Neuroscience, New Orleans, LA. Summary: Learning and memory remain largely intact following selective basal forebrain cholinergic lesions. By comparison, single unit recording studies have documented reliable […]

192-IgG saporin lesions of the medial septum and vertical diagonal band impair cognitive flexibility. Read More »

Discrete lesioning of orexin (hypocretin)-containing neurons potentiates dexmedetomidine- but not pentobarbital-induced hypnosis

Nelson LE, Franks NP, Maze M (2003) Discrete lesioning of orexin (hypocretin)-containing neurons potentiates dexmedetomidine- but not pentobarbital-induced hypnosis. Neuroscience 2003 Abstracts 426.13. Society for Neuroscience, New Orleans, LA. Summary: Introduction: Recent work suggests that anesthetics putatively modulated by the α2-adrenoceptor (e.g. dexmedetomidine (DEX)) or the GABAA receptor (e.g. pentobarbital (PTB)) elevate and depress c-Fos

Discrete lesioning of orexin (hypocretin)-containing neurons potentiates dexmedetomidine- but not pentobarbital-induced hypnosis Read More »

Dendritic dysgenesis in midline cortical regions following selective acetylcholine and dopamine lesions in neonatal rats

Sherren N, Pappas BA (2003) Dendritic dysgenesis in midline cortical regions following selective acetylcholine and dopamine lesions in neonatal rats. Neuroscience 2003 Abstracts 457.11. Society for Neuroscience, New Orleans, LA. Summary: Both acetylcholine (ACh) and dopamine (DA) afferents reach their cortical targets during periods of synaptogenesis, and are perfectly positioned to influence the cytoarchitectural development

Dendritic dysgenesis in midline cortical regions following selective acetylcholine and dopamine lesions in neonatal rats Read More »

Destruction of brainstem catecholamine neurons attenuates somatosympathetic reflex and responses to cholecystokinin

Neale JJ, Goodchild AK, Dampney RAL, Pilowsky PM (2003) Destruction of brainstem catecholamine neurons attenuates somatosympathetic reflex and responses to cholecystokinin. Neuroscience 2003 Abstracts 501.11. Society for Neuroscience, New Orleans, LA. Summary: The integrity of the rostral ventrolateral medulla (RVLM) is essential for the expression of many sympathetic reflexes and the maintenance of vasomotor tone.

Destruction of brainstem catecholamine neurons attenuates somatosympathetic reflex and responses to cholecystokinin Read More »

Tuberomammillary nucleus lesion decreases the anticipatory events induced by restricted feeding in rats

Recabarren MP, Valdes JL, Seron-Ferre M, Torrealba F (2003) Tuberomammillary nucleus lesion decreases the anticipatory events induced by restricted feeding in rats. Neuroscience 2003 Abstracts 510.19. Society for Neuroscience, New Orleans, LA. Summary: Our previous studies indicate that the histamine-containing neurons of the tuberomammillary nucleus (TMN) become active in anticipation to feeding time in rats

Tuberomammillary nucleus lesion decreases the anticipatory events induced by restricted feeding in rats Read More »

Neuroinflammatory response to mu p75-saporin immunotoxin-induced degeneration of basal forebrain cholinergic neurons

Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AE (2003) Neuroinflammatory response to mu p75-saporin immunotoxin-induced degeneration of basal forebrain cholinergic neurons. Neuroscience 2003 Abstracts 527.15. Society for Neuroscience, New Orleans, LA. Summary: Basal forebrain cholinergic neurons, which provide the major cholinergic innervation to the cortical regions and play a key role in the

Neuroinflammatory response to mu p75-saporin immunotoxin-induced degeneration of basal forebrain cholinergic neurons Read More »

Selective elimination of mu-opioid receptor expressing neurons in the rostral ventromedial medulla (RVM) does not affect periaqueductal gray (pag) stimulation-produced analgesia

Harasawa I, Lai J, Porreca F, Fields HL, Meng ID (2003) Selective elimination of mu-opioid receptor expressing neurons in the rostral ventromedial medulla (RVM) does not affect periaqueductal gray (pag) stimulation-produced analgesia. Neuroscience 2003 Abstracts 177.5. Society for Neuroscience, New Orleans, LA. Summary: PAG stimulation produces antinociception at spinal levels by modulating RVM neuronal activity.

Selective elimination of mu-opioid receptor expressing neurons in the rostral ventromedial medulla (RVM) does not affect periaqueductal gray (pag) stimulation-produced analgesia Read More »

Cholinergic activity enhances hippocampal CA1 long-term potentiation during walking in rats

Leung LS, Shen B, Ma J, Rajakumar N (2003) Cholinergic activity enhances hippocampal CA1 long-term potentiation during walking in rats. Neuroscience 2003 Abstracts 255.5. Society for Neuroscience, New Orleans, LA. Summary: Long-term potentiation (LTP) at the basal dendrites of CA1 pyramidal cells was induced by a single 200-Hz stimulation train (0.5-1 sec duration) in freely

Cholinergic activity enhances hippocampal CA1 long-term potentiation during walking in rats Read More »

H3 receptor antagonists modulate behaviour in a visual spatial attention task in rats with selective lesions of the nucleus basalis magnocellularis

Muir JL, Harrison FE (2003) H3 receptor antagonists modulate behaviour in a visual spatial attention task in rats with selective lesions of the nucleus basalis magnocellularis. Neuroscience 2003 Abstracts 296.7. Society for Neuroscience, New Orleans, LA. Summary: It is well known that the cholinergic system suffers a large amount of damage in Alzheimer’s Disease (AD).

H3 receptor antagonists modulate behaviour in a visual spatial attention task in rats with selective lesions of the nucleus basalis magnocellularis Read More »

Production and characterization of biotinylated gonadotropin-releasing hormone analogs conjugated to avidinylated saporin

Miller BT, Collins TJ (2003) Production and characterization of biotinylated gonadotropin-releasing hormone analogs conjugated to avidinylated saporin. Neuroscience 2003 Abstracts 325.15. Society for Neuroscience, New Orleans, LA. Summary: Saporin is a potent protein cytotoxin derived from the seeds of the plant Saponaria officinalis. Although unmodified saporin cannot permeate cellular membranes in appreciable amounts, this toxin

Production and characterization of biotinylated gonadotropin-releasing hormone analogs conjugated to avidinylated saporin Read More »

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