Author name: Kristen Hartman

Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation.

Rinaman L (2003) Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J Neurosci 23(31):10084-10092. doi: 10.1523/JNEUROSCI.23-31-10084.2003 Summary: Using 5-ng injections of anti-DBH-SAP (Cat. #IT-03) into hindbrain nucleus of the solitary tract in rats, the author investigated the role of DBH-positive neurons in the mediation of anorexigenic and […]

Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. Read More »

Extrinsic regulation of injury/growth-related gene expression in the inferior olive of the adult rat.

Buffo A, Carulli D, Rossi F, Strata P (2003) Extrinsic regulation of injury/growth-related gene expression in the inferior olive of the adult rat. Eur J Neurosci 18(8):2146-2158. doi: 10.1046/j.1460-9568.2003.02940.x Summary: Inferior olive (IO) cells of the CNS have the ability to regenerate axons after injury, even when the injury is close to the terminal field.

Extrinsic regulation of injury/growth-related gene expression in the inferior olive of the adult rat. Read More »

Cholinergic activity enhances hippocampal long-term potentiation in CA1 during walking in rats.

Leung LS, Shen B, Rajakumar N, Ma J (2003) Cholinergic activity enhances hippocampal long-term potentiation in CA1 during walking in rats. J Neurosci 23(28):9297-9304. doi: 10.1523/JNEUROSCI.23-28-09297.2003 Summary: To investigate the role of the cholinergic system in long term potentiation (LTP) the authors lesioned the left and right medial septum of rats with 0.14 µg of

Cholinergic activity enhances hippocampal long-term potentiation in CA1 during walking in rats. Read More »

Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection.

Dommergues MA, Plaisant F, Verney C, Gressens P (2003) Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience 121(3):619-628. doi: 10.1016/s0306-4522(03)00558-x Summary: Brain lesions that mimic damage from cerebral palsy in mice are characterized by microglial activation within 24 hours of insult. Using intraperitoneal injections of Mac-1-SAP (90

Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Read More »

Advanced Targeting Systems Awarded 2.4 Million Dollar SBIR Grant to Develop Revolutionary Chronic Pain Drug

SP SAP Drug Development /

San Diego, CA, October 7, 2003 – Advanced Targeting Systems, Inc. announced today that it has received a Small Business Innovative Research (SBIR) grant from the National Institute of Mental Health (NIMH) under the program announcement for pharmacologic agents and drugs to combat mental disorders. The three-year, $2.4 million award is a continuation of Phase

Advanced Targeting Systems Awarded 2.4 Million Dollar SBIR Grant to Develop Revolutionary Chronic Pain Drug Read More »

Targeting Tools: Rat-ZAP

News Tools /

Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent

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Targeting Article: CCK-SAP in Binding Studies

News Article /

Our thanks to Drs. Frank Porecca, Victory Hruby and Josephine Lai, Department of Pharmacology, The University of Arizona Health Sciences Center for sharing the results of their studies. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers

Targeting Article: CCK-SAP in Binding Studies Read More »

Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter.

Wiley RG, Harrison MB, Levey A, Lappi DA (2003) Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter. Cell Mol Neurobiol 23:839-850. doi: 10.1023/a:1025065306264 Summary: The authors demonstrate the effective and specific removal of neurons expressing the dopamine transporter in the substantia nigra pars compacta and the ventral tegmental area with

Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter. Read More »

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