Author name: Kristen Hartman

Zhu XO, de Permentier PJ, Waite PM (2002) Cholinergic depletion by IgG 192-saporin retards development of rat barrel cortex. Brain Res Dev Brain Res 136:1-16. doi: 10.1016/s0165-3806(02)00301-2 Summary: It has been shown that cholinergic afferents from the basal forebrain are necessary for normal cortical morphogenesis. However, the role of these projections in the development of […]

Birthelmer A, Dommes E, Jeltsch H, Cassel JC, Jackisch R (2002) Septal grafts and evoked acetylcholine release in the rat hippocampus after 192 IgG-saporin lesions. Neuroreport 13(7):973-976. doi: 10.1097/00001756-200205240-00015 Summary: The authors investigate the structural and behavioral effects of intrahippocampal grafts containing cholinergic neurons into a lesioned region of the brain. Previous studies in rats

Burk JA, Herzog CD, Porter MC, Sarter M (2002) Interactions between aging and cortical cholinergic deafferentation on attention. Neurobiol Aging 23:467-477. doi: 10.1016/s0197-4580(01)00315-3 Summary: Trauma to forebrain cholinergic neurons is suspected to make these neurons more susceptible to future age-related loss of function. The authors tested this theory by making incomplete lesions of the basal

Wang H, Germanson TP, Guyenet PG (2002) Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. J Neurosci 22(9):3755-3764. doi: 10.1523/JNEUROSCI.22-09-03755.2002 Summary: The pre-Bötzinger complex is a region of the ventral respiratory group (VRG) in the brain. Injection of excitatory amino acids into this

Li X, Conklin D, Ma W, Zhu X, Eisenach JC (2002) Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain 97:117-125. doi: 10.1016/s0304-3959(02)00011-8 Summary: T62 is a thiobene compound that enhances adenosine agonist binding to the A1 receptor. Activation of the adenosine receptor has been

Galani R, Lehmann O, Bolmont T, Aloy E, Bertrand F, Lazarus C, Jeltsch H, Cassel JC (2002) Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats. Physiol Behav 76:75-90. doi: 10.1016/s0031-9384(02)00674-1 Summary: Lesioning of the nucleus basalis magnocellularis (NBM) with 192-Saporin (Cat. #IT-01) has produced varied cognitive effects in numerous studies.

Berchtold NC, Kesslak JP, Cotman CW (2002) Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res 68(5):511-521. doi: 10.1002/jnr.10256 Summary: Brain-derived neurotrophic factor (BDNF) enhances neuron function and plasticity. The authors lesioned rats with medial septal injections of 192-Saporin (Cat #IT-01, 375 ng in 0.5 µl PBS) or OX7-SAP