Q: Why do your directions for SSP-SAP (Cat. #IT-11) state that it is to be used within hours after dissolution? To my knowledge, both proteins and peptides are stable in clean solution. A: In fact, the two components of SSP-SAP (Stable Substance P and Saporin) are quite stable. However, we have found that many things […]
Yoshimura N (2004) Featured Article: Effects of IB4-SAP on bladder overactivity. Targeting Trends 5(4) Related Products: IB4-SAP (Cat. #IT-10) Read the featured article in Targeting Trends. See Also: Nishiguchi J et al. Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation. Eur J Neurosci 20(2):474-482, 2004.
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Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213.Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004. It has been demonstrated that hyperexcitability of C-fibers in bladder afferent pathways can contribute to bladder overactivity and/or bladder pain under pathological conditions
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Cameron NM, Carey P, Erskine MS (2004) Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy. Brain Res 1022(1-2):137-147. doi: 10.1016/j.brainres.2004.07.022 Summary: Norepinephrine (NE) plays an important role in female reproductive function. While the ventral noradrenergic bundle is known to be necessary for transmitting the
Gerashchenko D, Chou TC, Blanco-Centurion CA, Saper CB, Shiromani PJ (2004) Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Sleep 27(7):1275-1281. doi: 10.1093/sleep/27.7.1275 Summary: Although evidence suggests that histaminergic neurons in the tuberomammillary nucleus (TMN) promote wakefulness, this has not been investigated using specific lesioning agents. In this study, the
Gertow K, Wolbank S, Rozell B, Sugars R, Andang M, Parish CL, Imreh MP, Wendel M, Ahrlund-Richter L (2004) Organized development from human embryonic stem cells after injection into immunodeficient mice. Stem Cells Dev 13:421-435. doi: 10.1089/scd.2004.13.421 PMID: 15345136 Summary: After thawing and brief drying, sections were fixed with 4% paraformaldehyde in PBS pH 7.4
Hudson B, Ritter S (2004) Hindbrain catecholamine neurons mediate consummatory responses to glucoprivation. Physiol Behav 82(2-3):241-250. doi: 10.1016/j.physbeh.2004.03.032 Summary: Norepinephrine (NE) and epinephrine (E) neurons appear to potently stimulate feeding behavior when administered to the hypothalamus. Previous work has indicated that these neurons play important roles in feeding responses due to glucoprivation. Bilateral 42 ng-injections
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Kudoh M, Seki K, Shibuki K (2004) Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex. Neurosci Res 50(1):113-123. doi: 10.1016/j.neures.2004.06.007 Summary: The auditory cortex (AC) is thought to play a role in the discrimination of sound sequences. The authors investigated the role of cholinergic inputs to the AC in
Ricceri L, Minghetti L, Moles A, Popoli P, Confaloni A, De Simone R, Piscopo P, Scattoni ML, di Luca M, Calamandrei G (2004) Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Exp Neurol 189(1):162-172. doi: 10.1016/j.expneurol.2004.05.025 Summary: A distinctive feature of Alzheimer’s disease is the loss of cholinergic
Works SJ, Wilson RE, Wellman CL (2004) Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex. Neurobiol Aging 25(7):963-974. doi: 10.1016/j.neurobiolaging.2003.08.003 Summary: Aged rats display more dramatic and longer lasting effects due to brain injury than young animals. The authors examined the role cholinergic neurons may play in brain plasticity after injury