SFN Poster of the Year 2004
Awarded by ATS at Society for Neuroscience (SFN) San Diego, California • October 23-27, 2004 Be sure to check out the cover article contributed by Dr. Pearson in our Targeting Trends newsletter (First Quarter, 2005). 858.6 IB4-SAP REDUCES IB4 STAINING IN THE SPINAL CORD AND PREVENTS AXOTOMY INDUCED SPROUTING OF Aß FIBERS M.S.Pearson*; M.Woods; G.T.Whiteside;
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Estrogen supports structural plasticity of the basal forebrain cholinergic system in vivo
Saenz C, Dominguez R, de Lacalle S (2004) Estrogen supports structural plasticity of the basal forebrain cholinergic system in vivo. Neuroscience 2004 Abstracts 72.11. Society for Neuroscience, San Diego, CA. Summary: It is known that estrogen (E2) modulates the structural plasticity of a variety of neurons, involving the activation of second messenger systems. We have
Loss of basal forebrain cholinergic neurons by 192 igG-Saporin induces increased IGF-II/M6P receptor expression in select brain areas
Hawkes CA, Kar S (2004) Loss of basal forebrain cholinergic neurons by 192 igG-Saporin induces increased IGF-II/M6P receptor expression in select brain areas. Neuroscience 2004 Abstracts 92.1. Society for Neuroscience, San Diego, CA. Summary: Alzheimer’s disease (AD) is characterized neuropathologically by the presence of extracellular amyloid plaques, intracellular neurofibrillary tangles and neuronal loss in selected
Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin induces activation of glycogen synthase kinase-3β activity
Kar S, Hawkes C, Jhamandas JH (2004) Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin induces activation of glycogen synthase kinase-3β activity. Neuroscience 2004 Abstracts 92.2. Society for Neuroscience, San Diego, CA. Summary: Glycogen synthase kinase-3β (GSK-3β) is a multifunctional enzyme involved in a variety of biological events including development, glucose metabolism and
Neurotrophic modulation of cholinergic denervation and hippocampal sympathetic ingrowth following immunolesioning with 192 IgG-saporin
Kolasa K, Parsons D, Conger K, Harrell LE (2004) Neurotrophic modulation of cholinergic denervation and hippocampal sympathetic ingrowth following immunolesioning with 192 IgG-saporin. Neuroscience 2004 Abstracts 92.9. Society for Neuroscience, San Diego, CA. Summary: Injection of specific cholinotoxin, 192 IgG-saporin into the medial septum (MS)of rat induces not only a selective cholinergic denervation of hippocampus
Role of noradrenergic mechanisms in sustained attention, impulse control, and effects of methylphenidate in rats: Possible relevance to ADHD
Milstein JA, Lehmann O, Theobald DEH, Dalley JW, Robbins TW (2004) Role of noradrenergic mechanisms in sustained attention, impulse control, and effects of methylphenidate in rats: Possible relevance to ADHD. Neuroscience 2004 Abstracts 123.6. Society for Neuroscience, San Diego, CA. Summary: There has been renewed interest in noradrenergic (NA) modulation of sustained attention and impulse
Targeting Tools: CCK-SAP
CCK-SAP (Cat. #IT-31) This new targeted toxin is a chemical conjugate of sulfonated cholecystokinin (CCK) and the ribosome-inactivating protein, saporin. CCK is widely distributed in the central nervous system and the gastrointestinal tract. CCK-SAP is an effective tool to study eating disorders and pain transmission. CCK-SAP eliminates cells recognizing sulfonated CCK. All other cells are
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Targeting Tools: NPY-SAP
NPY-SAP (Cat. #IT-28) NPY-SAP is a chemical conjugate of neuropeptide Y (NPY) and the ribosome-inactivating protein, saporin. NPY is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities,
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Targeting Tools: Anti-M-ZAP
Anti-M-ZAP (Cat. #IT-30) Anti-M-ZAP is another product in the line of second immunotoxins. Second immunotoxins are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin. The second immunotoxin uses the secondary antibody to “piggyback” onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Anti-M-ZAP is a chemical
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