Xu W, Zhu JPQ, Angulo JA (2004) Local striatal deletions of neurokinin-1 receptor-expressing neurons protect against methamphetamine-induced neural damage. Neuroscience 2004 Abstracts 908.8. Society for Neuroscience, San Diego, CA.
Summary: Recent collective evidence from our laboratory and others has implicated the peptidergic system involving the neuropeptide substance P (SP) and its receptor, neurokinin-1 (NK-1), in mediating METH-induced adverse effects in the neostriatum. Here we test to see if local striatal abolishment of the NK-1 receptor-signaling pathway can protect from METH-induced neural damage in the striatum. Selective striatal knockouts of this pathway was done using an intrastriatal injection of [Sar9,Met(O2)11]substance P conjugated to the ribosomal-inactivating cytotoxin saporin (SSP-SAP). Selective striatal elimination of NK-1 receptor-expressing neurons demonstrated protection against METH-induced apoptosis by TUNEL-labeling. This further confirms the important modulatory effects of this peptidergic receptor in striatum.
Related Products: SSP-SAP (Cat. #IT-11)