Q: Your targeted toxin kits come with different controls. I’m not sure of the best way to use them. For example, with the anti-SERT-SAP kit (Cat. # KIT-23) there is included unconjugated antibody, unconjugated saporin, and a control conjugate, mouse IgG-SAP. Should I use them all in the same experiment or for different purposes? A: […]
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Ma W, Eisenach JC (2007) Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation. Brain Res 1127(1):52-58. doi: 10.1016/j.brainres.2006.10.008 Summary: Peripheral nerve injury resulting in neuropathic pain often responds poorly to opioid treatment. alpha2-adrenoreceptor (AR) agonists, however, perform better after
Chauhan N (2007) Featured Article: Cholinergic immunolesioning produced tangle-like inclusions in TgCRND8 brain. Targeting Trends 8(1) Related Products: mu p75-SAP (Cat. #IT-16) Read the featured article in Targeting Trends. See Also: Chauhan NB Cholinergic immunolesioning produced tangle-like inclusions in TgCRND8 brain. Neuroscience 2006 Abstracts 271.8, 2006. Society for Neuroscience, Atlanta, GA
Contributed by Neelima Chauhan, Dept Anesthes/Anat & Cell Bio, Univ Illinois-Chicago;J. Brown VA Med Ctr Chicago, Chicago, IL and winner of the 2006 SfN Poster Award for work using ATS products. Today’s Alzheimer’s disease (AD) research lacks a “complete” model that would represent both plaque and tangle pathology together with correlative memory deficits. The currently
Whipple EC, Ditto AH, Shanahan RS, Gatesman JJ, Little SF, Taylor RP, Lindorfer MA (2007) Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys. Mol Immunol 44(4):377-388. doi: 10.1016/j.molimm.2006.02.032 PMID: 16631928 Related Products: Antibody to Complement C3 (10C7) (Cat. #AB-V80)
Read the 2006 Newsletters and recent scientific references 2006, issue 1: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin / by Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F / featuring CCK-SAP (Cat. #IT-31) SFN Poster of the Year Targeting Talk: LPS Content
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Schmeisser H, Kontsek P, Esposito D, Gillette W, Schreiber G, Zoon KC (2006) Binding Characteristics of IFN-alpha Subvariants to IFNAR2-EC and Influence of the 6-Histidine Tag. J Interferon Cytokine Res 26(12):866-876. doi: 10.1089/jir.2006.26.866 PMID: 17238829 Related Products: Antibody to 6-His (Cat. #AB-20)
Ohtori S, Inoue G, Koshi T, Ito T, Doya H, Moriya H, Takahashi K (2006) Substance P-saporin down-regulates substance P receptor immunoreactive sensory dorsal root ganglion neurons innervating the lumbar intervertebral discs in rats. Spine 31:2987-2991. doi: 10.1097/01.brs.0000250306.12996.fa Summary: Neurokinin-1 (NK-1) receptor expressing neurons that innervate lumbar intervertebral discs may be involved in lower back
Cabrera SM, Chavez CM, Corley SR, Kitto MR, Butt AE (2006) Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Behav Neurosci 120:298-306. doi: 10.1037/0735-7044.120.2.298 Summary: In humans, one aspect of cognitive flexibility is being able to shift attention under a variety of pressures. Here the authors suggest that lesions to the cholinergic nucleus
Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Read More »
Watson CS, Alyea RA, Hawkins BE, Thomas ML, Cunningham KA, Jakubas AA (2006) Estradiol effects on the dopamine transporter – protein levels, subcellular location, and function. J Mol Signal 1:5. doi: 10.1186/1750-2187-1-5 PMID: 17224081 Related Products: Dopamine Transporter Rat Monoclonal (DAT-ECD) (Cat. #AB-N17)