Author name: Kristen Hartman

Selective ablation of GABA neurons in the ventral tegmental area increases spontaneous locomotor activity.

Shank EJ, Seitz PK, Bubar MJ, Stutz SJ, Cunningham KA (2007) Selective ablation of GABA neurons in the ventral tegmental area increases spontaneous locomotor activity. Behav Neurosci 121:1224-1233. doi: 10.1037/0735-7044.121.6.1224 Summary: To further examine the importance of the ventral tegmental area (VTA) g-aminobutyric acid (GABA) neurons in behavioral function, the authors lesioned the VTA of […]

Selective ablation of GABA neurons in the ventral tegmental area increases spontaneous locomotor activity. Read More »

Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells

Lee G, Kim H, Elkabetz Y, Al Shamy G, Panagiotakos G, Barberi T, Tabar V, Studer L (2007) Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 25(12):1468-1475. doi: 10.1038/nbt1365 PMID: 18037878 Usage: Flow Cytometry cell sorting was performed using Anti-NGFr (p75). Related Products: NGFr (mu p75)

Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells Read More »

Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells.

Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML (2007) Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther 6:2995-3008. doi: 10.1158/1535-7163.MCT-07-0330 Summary: The human transferrin receptor (hTfR) is overexpressed in malignant cells.

Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Read More »

Food-elicited increases in cortical acetylcholine release require orexin transmission.

Frederick-Duus D, Guyton MF, Fadel J (2007) Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 149:499-507. doi: 10.1016/j.neuroscience.2007.07.061 Summary: In these experiments the authors examine the hypothesis that orexin fibers from the hypothalamus are necessary for basal forebrain cholinergic system (BFCS) activation in a food restriction model. Rats received 200 ng of orexin-SAP

Food-elicited increases in cortical acetylcholine release require orexin transmission. Read More »

Cholinergic saporin lesions in the nucleus accumbens attenuate alcohol drinking

Camp MC, Alcantara AA (2007) Cholinergic saporin lesions in the nucleus accumbens attenuate alcohol drinking. Neuroscience 2007 Abstracts 809.4/X26. Society for Neuroscience, San Diego, CA. Summary: Identifying specific cell types and the plasticity that occurs within those neuronal networks that lead to alcohol drinking is critical for the development of improved treatment programs for alcoholism.

Cholinergic saporin lesions in the nucleus accumbens attenuate alcohol drinking Read More »

Changes in neurokinin-1 receptor expression in populations of spinal lamina I neurons in rats lacking non-peptidergic nociceptive fibers

Saeed AW, Ribeiro-Da-Silva A (2007) Changes in neurokinin-1 receptor expression in populations of spinal lamina I neurons in rats lacking non-peptidergic nociceptive fibers. Neuroscience 2007 Abstracts 821.4/FF19. Society for Neuroscience, San Diego, CA. Summary: Neurokinin-1 receptor (NK-1r)-containing lamina I projection neurons are deeply involved in the transmission of pain-related information to the brain. Previous studies

Changes in neurokinin-1 receptor expression in populations of spinal lamina I neurons in rats lacking non-peptidergic nociceptive fibers Read More »

Antinociceptive effects of lumbar intrathecal neuropeptide y-saporin

Kline IV RH, Lemons LL, Wiley RG (2007) Antinociceptive effects of lumbar intrathecal neuropeptide y-saporin. Neuroscience 2007 Abstracts 821.5/FF20. Society for Neuroscience, San Diego, CA. Summary: Spinal intrathecal (i.t.) neuropeptide Y (NPY) has been shown to be antinociceptive in the rat. Using lumbar i.t. NPY, coupled to the ribosomal inactivating protein, saporin, to selectively destroy

Antinociceptive effects of lumbar intrathecal neuropeptide y-saporin Read More »

Immunotoxin lesion of cholinergic nucleus basalis magnocellularis neurons in Lister hooded rats impair performance in a delayed matching-to-place task

Savage S, Ogren S, Olson L, Mattsson A (2007) Immunotoxin lesion of cholinergic nucleus basalis magnocellularis neurons in Lister hooded rats impair performance in a delayed matching-to-place task. Neuroscience 2007 Abstracts 840.1/TT24. Society for Neuroscience, San Diego, CA. Summary: Central cholinergic systems play an important role in various aspects of cognition, and deficits in cortical

Immunotoxin lesion of cholinergic nucleus basalis magnocellularis neurons in Lister hooded rats impair performance in a delayed matching-to-place task Read More »

Early activation of the tuberomammillary nucleus is a common factor in appetitive behaviors in rats

Contreras M, Carrasco M, Riveros M, Quispe M, Valdes J, Torrealba F (2007) Early activation of the tuberomammillary nucleus is a common factor in appetitive behaviors in rats. Neuroscience 2007 Abstracts 842.19/WW11. Society for Neuroscience, San Diego, CA. Summary: Histamine neurons of the tuberomammillary nucleus show an earlier activation during the appetitive phase of feeding,

Early activation of the tuberomammillary nucleus is a common factor in appetitive behaviors in rats Read More »

Lesioning mu opioid receptor-containing neurons in the ventrolateral periaqueductal gray attenuates morphine analgesia in male but not female rats

Loyd DR, Murphy AZ (2007) Lesioning mu opioid receptor-containing neurons in the ventrolateral periaqueductal gray attenuates morphine analgesia in male but not female rats. Neuroscience 2007 Abstracts 921.4/NN15. Society for Neuroscience, San Diego, CA. Summary: Chronic pain will affect four out of five persons at some point across the lifespan. While the opioid-based narcotic morphine

Lesioning mu opioid receptor-containing neurons in the ventrolateral periaqueductal gray attenuates morphine analgesia in male but not female rats Read More »

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