Frederick-Duus D, Guyton MF, Fadel J (2007) Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 149:499-507. doi: 10.1016/j.neuroscience.2007.07.061
Summary: In these experiments the authors examine the hypothesis that orexin fibers from the hypothalamus are necessary for basal forebrain cholinergic system (BFCS) activation in a food restriction model. Rats received 200 ng of orexin-SAP (Cat. #IT-20) into the lateral hypothalamus/perifornical area. Lesioned animals that were also deprived of food displayed increased feeding latency when presented with food. These and other data indicate orexin in the BFCS is involved in attention to stimuli associated with homeostatic challenges.
Related Products: Orexin-B-SAP (Cat. #IT-20)