Awarded by ATS at Society for Neuroscience (SFN) San Diego, CA • November 3-7, 2007 Be sure to check out the cover article contributed by Dr. Pang in our Targeting Trends newsletter (First Quarter, 2008). 932.22/WW17 Understanding the role of non-cholinergic medial septal neurons in learning and memory: Implications for disease- and aging-related impairments*K Pang, […]
SFN Poster of the Year 2007 Read More »
Coons KD, Wilson RE, Sengelaub DR (2007) Protection from dendritic atrophy with testosterone following partial motoneuron depletion: dose-dependence in males and efficacy in females. Neuroscience 2007 Abstracts 56.11/S5. Society for Neuroscience, San Diego, CA. Summary: Partial depletion of motoneurons from the highly androgen-sensitive spinal nucleus of the bulbocavernosus (SNB), or the more typical somatic motoneuron
Ferguson AS, Sengelaub DR (2007) Dendritic atrophy following partial motoneuron depletion: time course of recovery and protection with testosterone. Neuroscience 2007 Abstracts 56.24/S18. Society for Neuroscience, San Diego, CA. Summary: In male rats, motoneurons of the spinal nucleus of the bulbocavernosus (SNB) project to the bulbocavernosus and levator ani (BC/LA) muscles, and both the motoneurons
Cai L, Johnson DA (2007) Poster: Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum. Neuroscience 2007 Abstracts 92.21/TT2. Society for Neuroscience, San Diego, CA. Summary: The goal of this project was to determine whether cholinergic neurons projecting from the medial septum (MS) to the hippocampus play
Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP (2008) Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology 54(2):269-279. doi: 10.1016/j.neuropharm.2007.09.014 Summary: Nocifensive behavior and cardiovascular responses due to nicotinic agonists may be sustained by substance P-positive primary afferents. Rats
Percaccio CR, Pruette AL, Mistry ST, Chen YH, Kilgard MP (2007) Sensory experience determines enrichment-induced plasticity in rat auditory cortex. Brain Res 1174:76-91. doi: 10.1016/j.brainres.2007.07.062 Summary: Animals housed in enriched environments display numerous signs of good neural health. In this work the authors examined the role acetylcholine plays in this plasticity. 2.6 µg of 192-IgG-SAP
Sensory experience determines enrichment-induced plasticity in rat auditory cortex. Read More »
Q: Can you tell me how I would calculate the amount of a SAP-type targeted toxin that I might want to buy based on a desire to bilaterally kill cells of interest within a typical diffusion zone around an injection site in a rodent brain? Use CRF-SAP (Cat. #IT-13) as an example. Are we talking
Cost of Targeted Toxin Read More »
Caudle RM (2007) Featured Article: Inducing central sensitization with a substance P/ cholera toxin conjugate. Targeting Trends 8(4) Related Products: SP-SAP (Cat. #IT-07), SP-CTA (Cat. #IT-39) Read the featured article in Targeting Trends. See Also: Caudle RM Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. BMC Neuroscience 8:30,
Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral
Ricceri L, Cutuli D, Venerosi A, Scattoni ML, Calamandrei G (2007) Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats. Behav Brain Res 183:111-117. doi: 10.1016/j.bbr.2007.05.035 Summary: In order to expand on previous work investigating the effect of early cholinergic lesions on processing of aversive stimuli the authors administered