Author name: Kristen Hartman

Featured Article: Ablation of GRPR+ neurons in the spinal cord by bombesin-saporin knocks out itch sensation in mice without affecting pain circuit

Chen ZF, Sun YG, Zhao ZQ, Meng XL, Yin J, Liu XY (2009) Featured Article: Ablation of GRPR+ neurons in the spinal cord by bombesin-saporin knocks out itch sensation in mice without affecting pain circuit. Targeting Trends 10(4) Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: […]

Featured Article: Ablation of GRPR+ neurons in the spinal cord by bombesin-saporin knocks out itch sensation in mice without affecting pain circuit Read More »

Cover Article: Ablation of GRPR+ Neurons in the Spinal Cord by Bombesin-Saporin Knocks Out Itch Sensation in Mice Without Affecting Pain Circuit

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Contributed by Zhou-Feng Chen, Yang-Gang Sun, Zhong-Qiu Zhao, Xiu-Li Meng, Jun Yin, Xian-Yu Liu; Washington University Pain Center School of Medicine, Dept of Anesthesiology, St. Louis, MO 63141 Unlike pain, itch sensation evokes scratching response instead of withdrawal behavior. However, itch and pain sensations share many similarities. Like chronic pain, chronic itch is a major clinical

Cover Article: Ablation of GRPR+ Neurons in the Spinal Cord by Bombesin-Saporin Knocks Out Itch Sensation in Mice Without Affecting Pain Circuit Read More »

Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task.

Lawhorn C, Smith DM, Brown LL (2009) Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task. Neuroscience 163(1):109-119. doi: 10.1016/j.neuroscience.2009.05.021 Summary: The functional role of basal ganglia striosomes is not well understood. In order to examine these cells in the context of motor behavior the authors injected 8.5 ng of

Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task. Read More »

Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration.

Montero M, Gonzalez B, Zimmer J (2009) Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration. Brain Res 1291:140-152. doi: 10.1016/j.brainres.2009.06.097 Summary: Data has shown microglia to be both neuroprotective and neurodegenerative in cerebral ischemia. This study presents a method for removing microglia from hippocampal slice cultures. Hippocampal slices from mouse were

Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration. Read More »

Spatial memory following selective cholinergic lesion of the nucleus basalis magnocellularis.

Dashniani M, Burjanadze M, Beselia G, Maglakelidze G, Naneishvili T (2009) Spatial memory following selective cholinergic lesion of the nucleus basalis magnocellularis. Georgian Med News 174:77-81. Summary: This study investigated the role of cholinergic nucleus basalis magnocellularis (NBM) cells in learning and memory. Rats received bilateral 200 ng injections of 192 IgG-SAP (Cat. IT-01) into

Spatial memory following selective cholinergic lesion of the nucleus basalis magnocellularis. Read More »

T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction.

Penaloza-MacMaster P, Masopust D, Ahmed R (2009) T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Immunology 128:164-171. doi: 10.1111/j.1365-2567.2009.03080.x Summary: Although antigen-specific T cells are vital to adaptive immune responses, they also contribute to a variety of diseases. In this work the authors examined the possibility of selectively removing epitope-specific T

T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Read More »

NGF is essential for hippocampal plasticity and learning.

Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH (2009) NGF is essential for hippocampal plasticity and learning. J Neurosci 29:10883-10889. doi: 10.1523/JNEUROSCI.2594-09.2009 Summary: This work aimed to define NGF modulation of plasticity and function in adults. Rats received 50 ng injections of 192-IgG-SAP (Cat. #IT-01) into the

NGF is essential for hippocampal plasticity and learning. Read More »

The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.

Zhu J, Xu W, Wang J, Ali SF, Angulo JA (2009) The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. J Neurochem 111(3):656-668. doi: 10.1111/j.1471-4159.2009.06330.x Summary: This study examined the role of neurokinin-1 receptors (NK1R) on the methamphetamine-induced apoptosis of striatal neurons. 4 ng of SSP-SAP (Cat. #IT-11) or the

The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. Read More »

Animal models of narcolepsy

Chen L, Brown RE, McKenna JT, McCarley RW (2009) Animal models of narcolepsy. CNS Neurol Disord Drug Targets 8(4):296-308. doi: 10.2174/187152709788921717 PMID: 19689311 Objective: To provide information to enable a consensus concerning the evaluation of narcoleptic behavioral and EEG phenomenology in these models. Related Products: Orexin-B-SAP (Cat. #IT-20) See Also: Gerashchenko K et al. Effects

Animal models of narcolepsy Read More »

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