Craig LA, Hong NS, Kopp J, McDonald RJ (2009) Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats. Brain Res Bull 79(1):53-62. doi: 10.1016/j.brainresbull.2008.10.013
Summary: It has been theorized that cognitive decline observed in Alzheimer’s disease is in part due to disruption of the circadian rhythm (CR) in these patients. Some basal forebrain cholinergic neurons project to the suprachiasmatic nucleus, which is responsible for maintenance of CR. Rats received two injections totaling 7.5 ng of 192-IgG-SAP (Cat. #IT-01) into the medial septum/diagonal band of Broca. Lesioned animals did not show any evidence of CR disruption.
Related Products: 192-IgG-SAP (Cat. #IT-01)