Author name: Kristen Hartman

Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice.

Nag N, Baxter MG, Berger-Sweeney JE (2009) Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice. Neurosci Lett 452:247-251. doi: 10.1016/j.neulet.2009.01.006 Summary: The authors tested a new version of mu p75-SAP (Cat. #IT-16) in mice. Mice received bilateral injections of 0.65 or 1.3 µg of immunotoxin into each lateral […]

Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice. Read More »

Derivation of neural crest cells from human pluripotent stem cells

Lee G, Chambers SM, Tomishima MJ, Studer L (2010) Derivation of neural crest cells from human pluripotent stem cells. Nat Protoc 5(4):688-701. doi: 10.1038/nprot.2010.35 PMID: 20360764 Summary: Protocols are presented for the purification and propagation of hPSC-NC cells using flow cytometry and defined in vitro culture conditions. This protocol has been validated in multiple independent

Derivation of neural crest cells from human pluripotent stem cells Read More »

A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement

Lindorfer MA, Pawluczkowycz AW, Peek EM, Hickman K, Taylor RP, Parker CJ (2010) A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement. Blood 115(11):2283-2291. doi: 10.1182/blood-2009-09-244285 PMID: 20068220 Related Products: Antibody to Complement C3

A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement Read More »

Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung

Corboz MR, Rivelli MA, Eckel SP (2010) Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung. Exp Lung Res 36(9):509-521. doi: 10.3109/01902141003777582 Related Products: NKB-SAP (Cat. #IT-63)

Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung Read More »

Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats.

Carstens EE, Carstens MI, Simons CT, Jinks SL (2010) Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats. Neuroreport 21:303-308. doi: 10.1097/WNR.0b013e328337310a Summary: The itch signal is passed through the superficial dorsal horn. The authors investigated whether ablation of NK-1 receptor-expressing neurons in this area would affect itch-related scratching behavior. Rats received 20 µl

Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats. Read More »

Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats.

Lujan HL, Palani G, Peduzzi J, Dicarlo SE (2010) Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats. Am J Physiol Regul Integr Comp Physiol 298(5):R1358-1365. doi: 10.1152/ajpregu.00755.2009 Summary: Autonomic dysreflexia is a life-threatening hypertension as a result of a spinal cord injury above thoracic

Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats. Read More »

Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning.

Conner JM, Kulczycki M, Tuszynski MH (2010) Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning. Cereb Cortex 20(11):2739-2748. doi: 10.1093/cercor/bhq022 Summary: This work mapped the basal cholinergic forebrain system associations with skilled motor learning and motor function recovery after cortical injury. Rats were lesioned with 192-IgG-SAP (Cat. #IT-01). The animals received

Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning. Read More »

Photochemical internalization (PCI): a technology for drug delivery.

Berg K, Weyergang A, Prasmickaite L, Bonsted A, Hogset A, Strand MT, Wagner E, Selbo PK (2010) Photochemical internalization (PCI): a technology for drug delivery. (eds. Gomer C). In: Photodynamic Therapy. Methods in Molecular Biology. 635:133-145. Humana Press, Totowa, NJ. doi: 10.1007/978-1-60761-697-9_10 Summary: This review discusses photochemical internalization (PCI), which is a method used to

Photochemical internalization (PCI): a technology for drug delivery. Read More »

The brainstem noradrenergic systems in stress, anxiety, and depression.

Itoi K, Sugimoto N (2010) The brainstem noradrenergic systems in stress, anxiety, and depression. J Neuroendocrinol 22(5):355-361. doi: 10.1111/j.1365-2826.2010.01988.x Summary: In this review the authors examine the relationship between the central noradrenergic system, fear/anxiety states, and depression. The use of anti-DBH-SAP (Cat. #IT-03) to investigate the function of the noradrenergic system in these paradigms is

The brainstem noradrenergic systems in stress, anxiety, and depression. Read More »

Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats.

Lujan HL, Palani G, Zhang L, Dicarlo SE (2010) Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats. Am J Physiol Heart Circ Physiol 298:H1330-H1339. doi: 10.1152/ajpheart.00955.2009 Summary: It has been shown that reduction of cardiac sympathetic activity protects against ventricular tachy-arrhythmias, which are the leading cause

Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats. Read More »

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