Author name: Kristen Hartman

Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory.

Zaichenko MI, Philenko P, Sidorina V, Grigoryan GA (2023) Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory. Biochemistry Moscow 88:526-538. doi: 10.1134/S0006297923040089 PMID: 37080938 Objective: Goal of the work was to conduct comparative analysis of the effects of acute and chronic lipopolysaccharide- […]

Acute and chronic lipopolysaccharide-induced stress changes expression of proinflammatory cytokine genes in the rat brain region-specifically and affects learning and memory. Read More »

Non-genotoxic restoration of the hematolymphoid system in fanconi anemia

Chan YY, Ho PY, Swartzrock L, Rayburn M, Nofal R, Thongthip S, Weinberg KI, Czechowicz A (2023) Non-genotoxic restoration of the hematolymphoid system in fanconi anemia. Transplant Cell Ther 29(3):164.e1-164.e9. doi: 10.1016/j.jtct.2022.08.015 PMID: 35995393 Objective: Evaluate the efficacy of different CD117 mAb agents and immunosuppression on hematopoietic stem cell (HSC) depletion, and their ability to

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Streptavidin-saporin: Converting biotinylated materials into targeted toxins

Targeting Topics /

This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and research performed using Streptavidin-ZAP and its impact on academia and industry for research and drug development are presented. Read the full article as

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia

Myers B, Islam S, Gleber Netto FO, Debnath KC, Srivastava S, Xie T, Akhter S, Adebayo AA, Miller J, Lothumalia S, Sathiskumar HN, Amit M (2023) Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia. Cancer Neuroscience Symposium Objective: Explore the hypothesis that modulation of cholinergic (CHAT+) and nociceptive

Targeting nociceptive and cholinergic nerves in irradiated oropharyngeal cancer model reveals novel mechanism for dysphagia Read More »

Streptavidin-saporin: Converting biotinylated materials into targeted toxins

Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2023) Streptavidin-saporin: Converting biotinylated materials into targeted toxins. Toxins 15(3):181. doi: 10.3390/toxins15030181 PMID: 36977072 Summary: This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate

Sonokawa T, Obi N, Usuda J, Sudo Y, Hamakubo T (2023) Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer 14(7):645-653. doi: 10.1111/1759-7714.14776 PMID: 36655546 Objective: Using a photo-sensitizer and red light to release Cetuximab-saporin to target cancer. Summary: Photodynamic therapy is a non-invasive cancer treatment using a photo-sensitizer

Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate Read More »

Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP

Targeting Topics /

Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060.  We would be pleased to send you our 2023 ATS calendar. Click here to provide us your

Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP Read More »

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Iqbal Z, Lei Z, Ramkrishnan AS, Liu S, Hasan M, Akter M, Lam YY, Li Y (2023) Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats. Commun Biol 6:10. doi: 10.1038/s42003-022-04405-6 PMID: 36604595 Objective: To identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats Read More »

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