Author name: Kristen Hartman

Featured Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology

LaPlante F (2013) Featured Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology. Targeting Trends 14(1) Related Products: Anti-ChAT-SAP (Cat. #IT-42), Rabbit IgG-SAP (Cat. #IT-35) Read the featured article in Targeting Trends. See Also: Laplante F et al. Reduction in cholinergic interneuron density in the nucleus accumbens attenuates local […]

Featured Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology Read More »

Cover Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology

News Article /

Contributed by François LaPlante. Dept of Psychiatry, McGill University, Montréal, QC, Canada A post-mortem reduction in the density of cholinergic interneurons in the ventral striatum or nucleus accumbens (N.Acc.) has been reported in schizophrenic brains.[1,2] In this region the cholinergic interneurons interact anatomically and functionally with the dopaminergic nerve terminals notably to dampen the effects

Cover Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology Read More »

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.

Kukkonen JP (2013) Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol 304(1):C2-32 . doi: 10.1152/ajpcell.00227.2012 Summary: This review updates an original review from a decade ago on the subject of orexins. These neuropeptides have been shown to be involved in sleep, wakefulness, appetite, metabolism, stress response, reward/addiction, and analgesia.

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Read More »

Targeting Trends 2012 Newsletter

Newsletter /

Read the 2012 Newsletters and recent scientific references 2012, issue 1:  Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry / by M St. Peters, M Sarter / featuring 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Anti-NGFr blocking antibody, Staining with FITC-labeled Anti-Saporin Targeting Tools: Antibody to Metabotropic Glutamate

Targeting Trends 2012 Newsletter Read More »

Identification and characterization of a sleep-active cell group in the rostral medullary brainstem.

Anaclet C, Lin JS, Vetrivelan R, Krenzer M, Vong L, Fuller PM, Lu J (2012) Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. J Neurosci 32(50):17970-17976. doi: 10.1523/JNEUROSCI.0620-12.2012 Summary: The authors attempt to locate and identify specific neuronal populations that promote sleep. One method utilized was 130-330 pg injections of

Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. Read More »

Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons.

Cusulin C, Monni E, Ahlenius H, Wood J, Brune J, Lindvall O, Kokaia Z (2012) Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons. Stem Cells 30:2657-2671. doi: 10.1002/stem.1227 Summary: The fusogenic role of microglia could be even more important after NSC transplantation into brains affected by neurodegenerative diseases associated with microglia

Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons. Read More »

Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus.

Kaminski KL, Watts AG (2012) Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus. J Neuroendocrinol 24(12):1517-1526. doi: 10.1111/j.1365-2826.2012.02363.x Summary: Corticosterone releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVH) control release of adrenocorticotropic hormone and

Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus. Read More »

Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma.

Kato J, O’Donnell RT, Abuhay M, Tuscano JM (2012) Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma. Oncoimmunology 1(9):1469-1475. doi: 10.4161/onci.21815 Summary: CD22 is a B-cell-specific antigen found on many B-cell malignancies. It is not expressed by stem cell precursors, and is rapidly internalized when bound by an

Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma. Read More »

Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature.

Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, McMullen NT, Rance NE (2012) Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proc Natl Acad Sci U S A 109(48):19846-19851. doi: 10.1073/pnas.1211517109 Summary: Menopause is marked by estrogen withdrawal, and also by hot flushes. Given the fact that hypothalamic levels

Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Read More »

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model.

Kerbler GM, Hamlin AS, Pannek K, Kurniawan ND, Keller MD, Rose SE, Coulson EJ (2013) Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. Neuroimage 66C:133-141. doi: 10.1016/j.neuroimage.2012.10.075 Summary: The authors examined the effectiveness of diffusion MRI using diffusion tensor imaging (DTI) and probabilistic tractography in detecting cholinergic loss in

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. Read More »

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