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Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.

Kukkonen JP (2013) Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol 304(1):C2-32 . doi: 10.1152/ajpcell.00227.2012

Summary: This review updates an original review from a decade ago on the subject of orexins. These neuropeptides have been shown to be involved in sleep, wakefulness, appetite, metabolism, stress response, reward/addiction, and analgesia. This broad spectrum of action affects many processes including neuronal excitation, synaptic plasticity, and cell death. The use of orexin-SAP (Cat. #IT-20) in some of this work is discussed.

Related Products: Orexin-B-SAP (Cat. #IT-20)