Tuscano JM, Kato J, Pearson D, Xiong C, Newell L, Ma Y, Gandara DR, O’Donnell RT (2012) CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy. Cancer Res 72(21):5556-5565. doi: 10.1158/0008-5472.CAN-12-0173 Summary: The median overall survival of patients with advanced, unresectable, non-small cell lung cancer is 9-12 mos. […]
Vetrivelan R, Fuller PM, Yokota S, Lu J, Saper CB (2012) Metabolic effects of chronic sleep restriction in rats. Sleep 35(11):1511-1520. doi: 10.5665/sleep.2200 Summary: In order to investigate whether there is a correlation between sleep and weight the authors administered 200 nl of a 0.1% solution of orexin-SAP (Cat. #IT-20) to the ventrolateral preoptic area
Metabolic effects of chronic sleep restriction in rats. Read More »
Ortiz-Barajas O, Ramos-Rodriguez J, Berrocoso E, Garcia Alloza M (2012) Limited effect of serotonergic denervation on beta-amyloid and cognitive impairment in APPswe/PS1dE9 mice. Neuroscience 2012 Abstracts 751.12. Society for Neuroscience, New Orleans, LA. Summary: Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by progressive cognitive and memory impairment. Amyloid-beta (Aβ) deposition, as senile plaques (SP),
Ostock CY, Lindenbach D, Jaunarajs KL, Dupre KB, Goldenberg A, Bhide NS, Bishop C (2012) Noradrenergic denervation by DBH saporin reduces behavioral responsivity to L-DOPA in the hemi-parkinsonian rat. Neuroscience 2012 Abstracts 758.06. Society for Neuroscience, New Orleans, LA. Summary: Dopamine (DA) replacement therapy with L-DOPA remains the most effective treatment for Parkinson’s disease (PD),
Biggs LM, Simonton AR, Meredith M (2012) Intercalated nucleus modulates chemosensory processing in medial amygdala. Neuroscience 2012 Abstracts 781.07. Society for Neuroscience, New Orleans, LA. Summary: The vomeronasal organ is necessary for interpretation by naive rodents (hamsters, mice) of many chemosensory signals. Information is relayed to medial amygdala (Me) via the accessory olfactory bulbs. FRA
Intercalated nucleus modulates chemosensory processing in medial amygdala. Read More »
Carr F, Géranton SM, Hunt SP (2012) Descending facilitation contributes to changes in dorsal horn gene expression in a rat model of inflammatory joint pain. Neuroscience 2012 Abstracts 785.07. Society for Neuroscience, New Orleans, LA. Summary: Chronic pain is associated with increased excitability and changes in gene expression within the dorsal horn. Descending facilitation from
Wang F, Eisenach JC, Peters CM (2012) Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat. Neuroscience 2012 Abstracts 785.11. Society for Neuroscience, New Orleans, LA. Summary: Background and Objective: The percentage of patients that develop chronic postsurgical pain can range
Schwartz MD, Dittrich L, Fisher SP, Lincoln W, Liu H, Miller MA, Warrier DR, Wilk AJ, Morairty SR, Kilduff TS (2012) Effects of a dual hypocretin receptor antagonist on sleep and wakefulness in rats. Neuroscience 2012 Abstracts 799.23. Society for Neuroscience, New Orleans, LA. Summary: Benzodiazepine receptor agonists promote sleep by activating GABAA receptors, leading
Effects of a dual hypocretin receptor antagonist on sleep and wakefulness in rats. Read More »
Gulisano M, Parenti R, Gulino R (2012) Neural plasticity in injured spinal cord. Neuroscience 2012 Abstracts 846.09. Society for Neuroscience, New Orleans, LA. Summary: Sonic hedgehog and Noggin are morphogenetic factors involved in neural induction and ventralization of the neural tube, but recent findings suggest that they could participate in regeneration and functional recovery after
Neural plasticity in injured spinal cord. Read More »
Jeong D, Lee J, Lee S, Kim S, Chang J (2012) Spatial memory facilitation by electrical stimulation of the medial septum in rats. Neuroscience 2012 Abstracts 851.01. Society for Neuroscience, New Orleans, LA. Summary: Recently, deep brain stimulation has been used to treat various neurological disorders. Some studies support that DBS can be a strategy
Spatial memory facilitation by electrical stimulation of the medial septum in rats. Read More »