Author name: Kristen Hartman

Featured Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation

Cunningham C (2012) Featured Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation. Targeting Trends 13(4) Related Products: mu p75-SAP (Cat. #IT-16) Read the featured article in Targeting Trends. See Also: Field RH et al. Prior pathology in the Basal forebrain cholinergic system predisposes to inflammation-induced working memory […]

Featured Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation Read More »

Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia.

Kato J, Satake N, O’Donnell RT, Abuhay M, Lewis C, Tuscano JM (2013) Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia. Leuk Res 37(1):83-88. doi: 10.1016/j.leukres.2012.09.010 Summary: Most cases of acute lymphoblastic leukemia (ALL) are of B-cell lineage. Although children with ALL have a high survival rate,

Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia. Read More »

Acetylcholine facilitates recovery of episodic memory after brain damage.

Croxson PL, Browning PG, Gaffan D, Baxter MG (2012) Acetylcholine facilitates recovery of episodic memory after brain damage. J Neurosci 32(40):13787-13795. doi: 10.1523/JNEUROSCI.2947-12.2012 Summary: Episodic memory is controlled by several interconnected brain structures. The order in which these structures sustain damage can affect the processes lost. In this work the authors performed numerous bilateral injections

Acetylcholine facilitates recovery of episodic memory after brain damage. Read More »

Cover Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation

News Article /

Contributed by Dr. Colm Cunningham, Trinity College, Institute of Neuroscience & School of Biochemistry and Immunology, Dublin, Ireland It is well established that peripheral inflammation can signal the intact CNS to bring about adaptive changes in behavior during the sickness response. However, during aging and dementia, the brain is particularly susceptible to the deleterious effects

Cover Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation Read More »

Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats.

Daubert DL, McCowan M, Erdos B, Scheuer DA (2012) Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats. J Physiol 590(Pt 19):4881-4895. doi: 10.1113/jphysiol.2012.232314 Summary: It has been proposed that the nucleus of the solitary tract (NTS) is highly involved in cardiovascular regulation. In light of the fact

Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats. Read More »

The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract.

Babalola PA, Fitz NF, Gibbs RB, Flaherty PT, Li PK, Johnson DA (2012) The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem 98(3):303-310. doi: 10.1016/j.nlm.2012.09.003 Summary: Steroid sulfatase inhibitors such as dehydroepiandrosterone (DHEAS) have memory-enhancing effects. Working with

The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Read More »

Form and function of the M4 cell, an intrinsically photosensitive retinal ganglion cell type contributing to geniculocortical vision.

Estevez ME, Fogerson PM, Ilardi MC, Borghuis BG, Chan E, Weng S, Auferkorte ON, Demb JB, Berson DM (2012) Form and function of the M4 cell, an intrinsically photosensitive retinal ganglion cell type contributing to geniculocortical vision. J Neurosci 32(39):13608-13620. doi: 10.1523/JNEUROSCI.1422-12.2012 PMID: 23015450 Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are cells that contain

Form and function of the M4 cell, an intrinsically photosensitive retinal ganglion cell type contributing to geniculocortical vision. Read More »

Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.

Zant JC, Rozov S, Wigren HK, Panula P, Porkka-Heiskanen T (2012) Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons. J Neurosci 32(38):13244-13254. doi: 10.1523/JNEUROSCI.5933-11.2012 Summary: The basal forebrain modulates many functions, among them the regulation of wakefulness and cortical arousal. Previous data has linked increases in histaminergic transmission to increases in

Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons. Read More »

Photochemical internalization (PCI) of HER2-targeted toxins: Synergy is dependent on the treatment sequence.

Berstad MB, Weyergang A, Berg K (2012) Photochemical internalization (PCI) of HER2-targeted toxins: Synergy is dependent on the treatment sequence. Biochim Biophys Acta 1820(12):1849-1858. doi: 10.1016/j.bbagen.2012.08.027 Summary: A majority of patients develop acquired resistance to trastuzumab, the monoclonal antibody recognizing HER2, coupled to a toxin as a breast cancer therapeutic. One of the modes of

Photochemical internalization (PCI) of HER2-targeted toxins: Synergy is dependent on the treatment sequence. Read More »

Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance.

Paolone G, Lee TM, Sarter M (2012) Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance. J Neurosci 32(35):12115-12128. doi: 10.1523/JNEUROSCI.2271-12.2012 Summary: This work examined the role that neuronal mechanisms have in cognitive performance on a fixed-time task. The authors performed bilateral 160 ng infusions of 192-IgG-SAP (Cat. #IT-01) into the

Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance. Read More »

Search
Shopping Cart
Scroll to Top