Author name: Kristen Hartman

Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate

Sonokawa T, Obi N, Usuda J, Sudo Y, Hamakubo T (2023) Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer 14(7):645-653. doi: 10.1111/1759-7714.14776 PMID: 36655546 Objective: Using a photo-sensitizer and red light to release Cetuximab-saporin to target cancer. Summary: Photodynamic therapy is a non-invasive cancer treatment using a photo-sensitizer […]

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Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP

Targeting Topics /

Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060.  We would be pleased to send you our 2023 ATS calendar. Click here to provide us your

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Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Iqbal Z, Lei Z, Ramkrishnan AS, Liu S, Hasan M, Akter M, Lam YY, Li Y (2023) Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats. Commun Biol 6:10. doi: 10.1038/s42003-022-04405-6 PMID: 36604595 Objective: To identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats Read More »

Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease

Leanza G, Zorec R (2023) Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease. Function (Oxf) 4(1):zqac060., IT. doi: 10.1093/function/zqac060 PMID: 36590326 Summary: These results indicate a prominent role of NA-neurons vs. ACh neurons in impairments of working memory, relevant for AD, and are consistent with an astrocyte-specific metabolic impairment in a mouse model of intellectual disability.

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The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats

Fullerton E (2022) The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats. Georgia State University Thesis. doi: 10.57709/30509896 Objective: To investigate the impact of advanced age on the antihyperalgesic effect of morphine, as well as its association with changes

The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats Read More »

Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis

Maunze B (2022) Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis. Marquette University Dissertations 1212. Thesis. Objective: To determine the endogenous role of pituitary adenylate cyclase activating polypeptide (PACAP) in affecting the ventromedial nuclei (VMN) of the hypothalamus and its control of feeding and energy expenditure through the Type I PAC1

Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis Read More »

Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats.

Liu H, Xue Y, Chen L (2022) Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Metab Brain Dis 38:573-587. doi: 10.1007/s11011-022-01127-w PMID: 36454502 Objective: To investigate the functions of angiotensin II (Ang II)/angiotensin subtype 1 receptor (AT1R) on the globus pallidus neurons of both normal and Parkinsonian

Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Read More »

GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein

Hoffman S, Alvares D, Adeli K (2022) GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein. Mol Metab 65:101590. doi: 10.1016/j.molmet.2022.101590 PMID: 36067913 Objective: To examine the effect of vagal GLP-1 signaling on intestinal fat absorption and lipoprotein production. Summary: Selective deafferentation of GLP-1R-containing nodose neurons with

GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein Read More »

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190 Objective: To use a new murine testing model

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells Read More »

A role for thalamic projection GABAergic neurons in circadian responses to light

Brock O, Gelegen CE, Sully P, Salgarella I, Jager P, Menage L, Mehta I, Jęczmień-Łazur J, Djama D, Strother L, Coculla A, Vernon A, Brickley S, Holland P, Cooke S, Delogu A (2022) A role for thalamic projection GABAergic neurons in circadian responses to light. J Neurosci 42(49):9158-9179. doi: 10.1523/JNEUROSCI.0112-21.2022 PMID: 36280260 Related Products: Melanopsin

A role for thalamic projection GABAergic neurons in circadian responses to light Read More »

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