Zhang JJ, Song CG, Dai JM, Li L, Yang XM, Chen ZN (2022) Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor. MedComm 3(3):e148. doi: 10.1002/mco2.148 PMID: 35774845 Objective: To examine the mechanism of opioid addiction, with a specific focus on the reward circuitry and the role of […]
ABSTRACT When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to unique extracellular target), an appropriate place to begin is with the Nobel Prize-winning work of Paul Ehrlich and his concept of the “magic bullet.” Over 100 years later, the use of targeted toxins to perform molecular neurosurgery has become
A Brief History of Saporin and its Contributions to Neuroscience Read More »
Q: Does Mab-ZAP (Cat. #IT-04) bind to the FC portion of mouse IgG? A: The antibody used to create our Mab-ZAP (IT-04), will react with whole molecule mouse IgG, which includes the Fc portion and the two antigen binding Fab portions. Related Products: ZAP Conjugates
Mab-ZAP binds to Fc portion of mouse IgG Read More »
Q: Can your FabFc-ZAP human (Cat# IT-65) bind to the Fc portion of another species, such as mouse IgG? It looks like it binds to mouse IgG in our assay. A: The antibody used to create our FabFc-ZAP Human (IT-65), can react with the Fc (gamma) portion of human IgG heavy chain and should not
FabFc-ZAP cross-reaction with another species Read More »
Kim S, Shukla RK, Kim E, Cressman SG, Yu H, Baek A, Choi H, Kim A, Sharma A, Wang Z, Huang CA, Reneau JC, Boyaka PN, Liyanage NPM, Kim S (2022) Comparison of CD3e antibody and CD3e-sZAP immunotoxin treatment in mice identifies szap as the main driver of vascular leakage. Biomedicines 10(6):1221. doi: 10.3390/biomedicines10061221 Objective:
Griffin JM, Healy FM, Dahal LN, Floisand Y, Woolley JF (2022) Worked to the bone: antibody-based conditioning as the future of transplant biology. J Hematol Oncol 15(1):65. doi: 10.1186/s13045-022-01284-6 Objective: To analyze the current status of antibody-based drugs in pre-transplant conditioning regimens and assess their potential in the future of transplant biology. Summary: This review
Worked to the bone: antibody-based conditioning as the future of transplant biology Read More »
Krieger JP, Asker M, Van der Velden P, Börchers S, Richard JE, Maric I, Longo F, Singh A, De Larigue G, Skibicka KP (2022) Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior. Biological Psychiatry in press. doi: 10.1016/j.biopsych.2022.04.020 Objective: To determine how the sensing
Copeland EN (2022) Characterizing SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mdx mice. Brock University St. Catharines, Ontario, Canada Thesis. PMID: 0 Objective: To investigate the differences between two models of Duchenne muscular dystrophy (DMD): D2 mouse model with young mice showing cognitive deficits, and C57,
Bosecke C (2022) A novel anxiety process biomarker via electrovestibulography. University of Manitoba Thesis. Objective: Use electrophysiological technique of Electrovestibulography to measure field potentials caused by vestibular neurons in the ear canal in order to identify biomarkers associated with anxiety disorder. Summary: Anxiety disorders have no known biomarkers and are diagnosed based on symptoms. Identifying
A novel anxiety process biomarker via electrovestibulography Read More »
Ahn JP (2022) Ablation of dorsomedial striatum patch compartment results in modification to reward-driven behaviors in rats. Mercer University School of Medicine Thesis. Objective: This thesis intended to demonstrate that selective ablation of dorsomedial striatum (DMS) patch compartment neurons results in a significant impact on the initial development of reward-driven behaviors during the early stages