Author name: Kristen Hartman

A novel anxiety process biomarker via electrovestibulography

Bosecke C (2022) A novel anxiety process biomarker via electrovestibulography. University of Manitoba Thesis. Objective: Use electrophysiological technique of Electrovestibulography to measure field potentials caused by vestibular neurons in the ear canal in order to identify biomarkers associated with anxiety disorder. Summary: Anxiety disorders have no known biomarkers and are diagnosed based on symptoms. Identifying […]

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Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs.

Li Y, Ye Z, Yang H, Xu Q (2022) Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Acta Pharm Sin B 12(6):2624-2639. doi: 10.1016/j.apsb.2022.04.013 Objective: To highlight the recent progress in combinatorial lipid nanoparticles (LNPs) with novel structures and properties for the delivery of small- and macromolecular therapeutics. Summary: The

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Read More »

Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia

Chen LQ, Lv XJ, Guo QH, Lv SS, Lv N, Yu J, Xu WD, Zhang YQ (2022) Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia. bioRxiv 2022.04.16.488241. doi: 10.1101/2022.04.16.488241 Related Products: Mac-1-SAP rat (Cat. #IT-33)

Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia Read More »

Impact of limb phenotype on tongue denervation atrophy, dysphagia penetrance, and survival time in a mouse model of ALS

Mueller M, Thompson R, Osman KL, Andel E, DeJonge CA, Kington S, Stephenson Z, Hamad A, Bunyak F, Nichols NL, Lever TE (2022) Impact of limb phenotype on tongue denervation atrophy, dysphagia penetrance, and survival time in a mouse model of ALS. Dysphagia doi: 10.1007/s00455-022-10442-4 Related Products: CTB-SAP (Cat. #IT-14) See Also: Lind LA et

Impact of limb phenotype on tongue denervation atrophy, dysphagia penetrance, and survival time in a mouse model of ALS Read More »

Purification of fibroblasts from the spiral ganglion

Anacker A, Esser KH, Lenarz T, Paasche G (2022) Purification of fibroblasts from the spiral ganglion. Front Neurol 13:877342. doi: 10.3389/fneur.2022.877342 PMID: 35493807 Objective: To provide a purified preparation of cochlear fibroblasts, which can be used in vitro for further investigations. Summary: Subcultivation of the primary spiral ganglion cells culture removed the neurons from the

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Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease

Liu W, Li J, Yang M, Ke X, Dai Y, Lin H, Wang S, Chen L, Tao J (2022) Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease. Alzheimers Res Ther 14(1):53. doi: 10.1186/s13195-022-00994-w Related Products: 192-IgG-SAP (Cat. #IT-01) See Also: Tomaszewicz M et al. Changes in cortical

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease Read More »

P2X7 receptor augments LPS-induced nitrosative stress by regulating Nrf2 and GSH levels in the mouse hippocampus

Lee DS, Kim JE (2022) P2X7 receptor augments LPS-induced nitrosative stress by regulating Nrf2 and GSH levels in the mouse hippocampus. Antioxidants (Basel) 11(4):778. doi: 10.3390/antiox11040778 PMID: 35453462 Objective: To elucidate whether P2X7R affects nuclear factor-erythroid 2-related factor 2 (Nrf2) activity/expression and glutathione (GSH) synthesis under nitrosative stress in response to lipopolysaccharide (LPS)-induced neuroinflammation. Summary:

P2X7 receptor augments LPS-induced nitrosative stress by regulating Nrf2 and GSH levels in the mouse hippocampus Read More »

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