Fraser M, Fortier M, Foucher D, Roumier P, Brousseau P, Fournier M, Surette C, Vaillancourt C (2018) Exposure to low environmental concentrations of manganese, lead, and cadmium alters the serotonin system of blue mussels. Environ Toxicol Chem 37:192-200. doi: 10.1002/etc.3942 PMID: 28796292 Objective: To determine the effects of exposure to Mn, Pb, or Cd on […]
Lindborg JA, Mack M, Zigmond RE (2017) Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. J Neurosci 37(43):10258-10277. doi: 10.1523/JNEUROSCI.2085-17.2017 PMID: 28912156 Objective: To characterize Wallerian degeneration (WD) in male Ccr2−/−mice and identify a compensatory mechanism of WD that is facilitated primarily by neutrophils. Summary: The data have
Llorente-ovejero A, Manuel I, Giralt MT, Rodríguez-puertas R (2017) Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction. Neuroscience 362:206-218.. doi: 10.1016/j.neuroscience.2017.08.008 Objective: To evaluate the eCB signaling in relation to the memory impairment induced in adult rats following a specific cholinergic lesion of the basal forebrain. Summary: CB1 receptors
Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse
Better Gene Therapy Through Targeting Read More »
Leduc-Pessah H, Weilinger N, Fan C, Burma N, Thompson R, Trang T (2017) Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance. J Neurosci 37:10154-10172.. doi: 10.1523/JNEUROSCI.0852-17.2017 Summary: By selectively ablating microglia in the spinal cord using a Mac-1-SAP the authors demonstrate a causal role for microglia in the development, but not
Zielinski M, Gerashchenko D (2017) Sleep-inducing effect of substance P-cholera toxin A subunit in mice. Neurosci Lett 659:44-47.. doi: 10.1016/j.neulet.2017.08.066 Objective: To determine the effects of selectively activating SP-expressing brain cells on sleep regulation in mice. Summary: ICV administration of SP-CTA produces increased amounts of NREM sleep but induces sleep fragmentation. Usage: 1 mcg/mcl icv.
Sleep-inducing effect of substance P-cholera toxin A subunit in mice. Read More »
Xiao H, Li M, Cai J, Li N, Zhou M, Wen P, Xie Z, Wang Q, Chang J, Zhang W (2017) Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats. Neurosci Lett 659:92-98.. doi: 10.1016/j.neulet.2017.08.016 Summary: Many patients with advanced Parkinson’s disease suffer from gait and postural impairments. The authors
Congratulations to winners of the Nobel Prize in Physiology or Medicine 2017: Jeffrey C. Hall, Michael Rosbash, Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. Circadian aspects of adipokine regulation in rodents. Challet E, Best Practice & Research Clinical Endocrinology & Metabolism (2017), doi: 10.1016/j.beem.2017.09.003. This paper reviews reciprocal links between the
Nobel Prize for Discoveries of Molecular Mechanisms of Circadian Rhythm Read More »
Komatsu N, Mitsui K, Kusano-Arai O, Iwanari H, Hoshi K, Takato T, Abe T, Hamakubo T (2017) Enhancement of anti-Robo1 immunotoxin cytotoxicity to head and neck squamous cell carcinoma via photochemical internalization. Arch Can Res 5:157-163. doi: 10.21767/2254-6081.100157 Objective: To screen a monoclonal antibody to Robo1, an axon guidance receptor, for its suitability to target
Rosen S, Ham B, Drouin S, Boachie N, Chabot-Dore A, Austin J, Diatchenko L, Mogil J (2017) T-cell mediation of pregnancy analgesia affecting chronic pain in mice. J Neurosci 37:9819-9827.. doi: 10.1523/JNEUROSCI.2053-17.2017 Related Products: Mac-1-SAP mouse/human (Cat. #IT-06)
T-cell mediation of pregnancy analgesia affecting chronic pain in mice. Read More »