Author name: Kristen Hartman

Tools to study neuroplasticity induced by chronic use of opioids

Targeting Topics /

SSP-SAP [Stable analog of Substance P conjugated to Saporin] (Cat. #IT-11) Objective:  To determine the the mechanisms mediating the induction of opioid-induced hyperalgesia and the prolongation of prostaglandinE2-induced hyperalgesia in type II hyperalgesic priming. Summary:  The authors show that understanding the mechanisms responsible for the induction of type II hyperalgesic priming, a form of neuroplasticity in the […]

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Circuit dissection of the role of somatostatin in itch and pain

Huang J, Polgár E, Solinski HJ, Mishra SK, Tseng PY, Iwagaki N, Boyle KA, Dickie AC, Kriegbaum MC, Wildner H, Zeilhofer HU, Watanabe M, Riddell JS, Todd AJ, Hoon MA (2018) Circuit dissection of the role of somatostatin in itch and pain. Nat Neurosci 21(5):707-716. doi: 10.1038/s41593-018-0119-z Objective: To determine the role of somatostatin in

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Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain

Lee S, Shi XQ, Fan A, West B, Zhang J (2018) Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Mol Pain 14:1744806918764979. doi: 10.1177/1744806918764979 Summary: Depletion of spinal microglia with Mac-1-SAP was able to prevent and reverse neuropathic pain behavior. Related Products:

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain Read More »

Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance

Ing-Esteves S, Kostadinov D, Marocha J, Sing AD, Joseph KS, Laboulaye MA, Sanes JR, Lefebvre JL (2018) Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance. J Neurosci 38:2713-2729. doi: 10.1523/JNEUROSCI.3035-17.2018 PMID: 29439167 Objective: The clustered protocadherins (Pcdhs) comprise 58 cadherin-related proteins encoded by three tandemly arrayed gene clusters, Pcdh- , Pcdh-

Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance Read More »

Catecholamine neurons in Obesity

Targeting Topics /

Anti-DBH-SAP, Cat. #IT-03[Dopamine Beta Hydroxylase antibody conjugated to Saporin] Objective: To investigate the role of hindbrain catecholamine neuron pathways and their contribution to long-term energy homeostasis by controlling obesogenic sensitivity to a high-fat, high sucrose choice diet. Summary: The authors show that catecholamine neurons (primarily in the VLM and NTS) convey essential feedback signals to

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Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: Implications for bicuspid aortic valve-related aortopathy

Jiao J, Tian W, Qiu P, Norton EL, Wang MM, Chen YE, Yang B (2018) Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: Implications for bicuspid aortic valve-related aortopathy. J Thorac Cardiovasc Surg 156:515-522. doi: 10.1016/j.jtcvs.2018.02.087 PMID: 29653750 Objective: To develop an in vitro model with

Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: Implications for bicuspid aortic valve-related aortopathy Read More »

Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling

Xu K, Pan X, Qiu X, Wang D, Dong N, Yang L, Li S (2018) Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling. Wound Repair Regen 26(1):54-63. doi: 10.1111/wrr.12614 PMID: 29381243 Objective: To investigate the role of neural crest (NC)-derived cells in tendon regeneration. Summary: It is concluded that after Achilles

Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling Read More »

The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor.

Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K (2018) The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. J Neurosci 38:2589-2604. doi: 10.1523/JNEUROSCI.0953-17.2018. PMID: 29440387 Objective: To investigate whether the soluble form of LOTUS (s-LOTUS) also has

The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. Read More »

Streptavidin-Saporin key ingredient in Immunotoxin Cocktail

Targeting Topics /

Streptavidin-ZAP[Streptavidin conjugated to Saporin](Cat. #IT-27) Objective: To determine if an immunotoxin cocktail targeted to multiple epitopes has synergistic effects on low expression level cells, which would expand the applicable range of immunotoxin therapy for cancer. Summary: The combination of immunotoxins with different mechanisms of action in an antibody cocktail will increase cytotoxic activities and decrease

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Low osteogenic yield in human pluripotent stem cells associates with differential neural crest promoter methylation

Sparks NRL, Martinez IKC, Soto CH, Zur Nieden NA-O (2018) Low osteogenic yield in human pluripotent stem cells associates with differential neural crest promoter methylation. Stem Cells 36:349-362. doi: 10.1002/stem.2746 PMID: 29193426 Objective: To compare the osteogenic potential of two human induced pluripotent stem cell lines (RIV9 and RIV4) to human H9 embryonic stem cells.

Low osteogenic yield in human pluripotent stem cells associates with differential neural crest promoter methylation Read More »

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