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Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance

Ing-Esteves S, Kostadinov D, Marocha J, Sing AD, Joseph KS, Laboulaye MA, Sanes JR, Lefebvre JL (2018) Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance. J Neurosci 38:2713-2729. doi: 10.1523/JNEUROSCI.3035-17.2018

Objective: The clustered protocadherins (Pcdhs) comprise 58 cadherin-related proteins encoded by three tandemly arrayed gene clusters, Pcdh- , Pcdh- , and Pcdh- (Pcdha, Pcdhb, and Pcdhg, respectively). This study sought to determine roles of Pcdhas and Pcdhgs in the retina and cerebellum from mice (both sexes) lacking one or both clusters.

Summary: Study examined two regions of the CNS, the retina and cerebellum and showed that the 14 -Pcdhs and 22 -Pcdhs act synergistically to mediate neuronal survival and dendrite patterning. In retina, Pcdhgs are essential for survival of inner retinal neurons and dendritic self-avoidance of starburst amacrine cells, whereas Pcdhas are dispensable for both processes.

Usage: Anti-Melanopsin (1:5000) used to quantify two mutually exclusive RGC cell types, the Brn3a RGCs and the melanopsin-positive intrinsically photo- sensitive RGCs (Mel ipRGCs).

Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

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