Sonic Hedgehog and TDP-43 Participate in the Spontaneous Locomotor Recovery in a Mouse Model of Spinal Motoneuron Disease. Rosario Gulino *, Rosalba Parenti and Massimo Gulisano
J. Funct. Morphol. Kinesiol. 2017, 2(2), 11; doi:10.3390/jfmk2020011
The authors used a mouse model of neurotoxic motoneuron depletion to study the role of Sonic hedgehog and TDP-43 in the compensatory changes occurring after the lesion. The injection of cholera toxin-B saporin (CTB-SAP; Cat. #IT-14) into the gastrocnemius muscle caused a partial motoneuron death accompanied by an impairment of locomotion. Motor activity was significantly restored as soon as one month later.
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