11q3

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology …

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Targeting Trends 2011 Newsletter

2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Product Questions Targeting Tools: Anti-DBH-SAP (Cat. #IT-03) targets dopamine beta-hydroxylase 2011, issue 2: Carrageenan evoked P-Akt in deep …

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Targeting Talk: Product Questions

Regarding Secondary Conjugates I would like to know if the secondary antibody used to prepare Mab-ZAP (Cat. #IT-04) reagent binds to heavy chain of mIgG’s (only) or if it recognizes light chains as well? Mab-ZAP will recognize whole IgG and will bind to both the heavy and light chain. We’ve been using Mab-ZAP to test …

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Targeting Topics 11q3

BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Angelucci F, Gelfo F, Bartolo PD, Caltagirone C, Petrosini L. Neurochem Int 59(1):1-4, 2011. Brain-derived neurotrophic factor (BDNF) plays a role in neuronal function during the degeneration of neurons caused by pathological conditions such as Alzheimer’s disease. …

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