11q3

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology …

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Targeting Trends Newsletter 11q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Incubator Labs; IBRO Abstracts (page 2) Cytotoxicity Assays (page 5) Teaser Winners (page 6) New Antibody Conjugates (page 7) Complete and Submit the Targeting Teaser …

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Targeting Talk: Product Questions

Regarding Secondary Conjugates I would like to know if the secondary antibody used to prepare Mab-ZAP (Cat. #IT-04) reagent binds to heavy chain of mIgG’s (only) or if it recognizes light chains as well? Mab-ZAP will recognize whole IgG and will bind to both the heavy and light chain. We’ve been using Mab-ZAP to test …

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Targeting Topics 11q3

BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Angelucci F, Gelfo F, Bartolo PD, Caltagirone C, Petrosini L. Neurochem Int 59(1):1-4, 2011. Brain-derived neurotrophic factor (BDNF) plays a role in neuronal function during the degeneration of neurons caused by pathological conditions such as Alzheimer’s disease. …

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