11q2

Targeting Trends 2011 Newsletter

2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Product Questions Targeting Tools: Anti-DBH-SAP (Cat. #IT-03) targets dopamine beta-hydroxylase 2011, issue 2: Carrageenan evoked P-Akt in deep …

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Targeting Tools: FGF-2 Human Recombinant

Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration …

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Targeting Talk: Product Questions

Regarding Custom Saporin Conjugations We recently spoke to you about performing a custom saporin conjugation (see Custom Conjugates) using our antibody. Is 0.09% azide in PBS in the antibody stock acceptable? There are a number of dialysis steps within the conjugation protocol that will ultimately remove the azide from your antibody solution. So as long …

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Targeting Topics 11q2

Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion. Antonini V, Marrazzo A, Kleiner G, Coradazzi M, Ronsisvalle S, Prezzavento O, Ronsisvalle G, Leanza G. J Alzheimers Dis, 24(3):569-586, 2011. Sigma-1 receptor agonists such as (-)-MR22 are potential therapeutic drugs for the treatment of cognitive …

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Targeting Article: Basigin-2 (EMMPRIN), a Prognostic Marker, is a Dynamic Portal of Entry into Cancer Cells

by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for …

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Cover Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn

Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed …

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