Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Basigin-2 poster (page 2) Teaser Winners (page 2) Customs, Conjugates, and Toxicity (page 5) Featured Recombinant Proteins (page 7) Complete and Submit the Targeting Teaser …
Granulocyte Macrophage Colony Stimulating Factor (GM CSF) is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with …
Growth Hormone (GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved …
Targeting Tools: Growth Hormone Human Recombinant Read More »
Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration …
Leptin is a 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. It provides the key afferent signal from fat cells in the feedback system that controls body fat stores. Leptin Human Recombinant, Cat. #PRP-328 available in these sizes: 200 micrograms, 1 milligram, and 5 milligrams …
Regarding Custom Saporin Conjugations We recently spoke to you about performing a custom saporin conjugation (see Custom Conjugates) using our antibody. Is 0.09% azide in PBS in the antibody stock acceptable? There are a number of dialysis steps within the conjugation protocol that will ultimately remove the azide from your antibody solution. So as long …
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion. Antonini V, Marrazzo A, Kleiner G, Coradazzi M, Ronsisvalle S, Prezzavento O, Ronsisvalle G, Leanza G. J Alzheimers Dis, 24(3):569-586, 2011. Sigma-1 receptor agonists such as (-)-MR22 are potential therapeutic drugs for the treatment of cognitive …
by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for …
Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed …