10q1

Targeting Trends 2010 Newsletter

2010, issue 1: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats / by Li AJ, Wang Q, Dinh TT, Ritter S / featuring Leptin-SAP (Cat. #IT-47) and Blank-SAP (Cat. #IT-21) SFN Poster of the Year Targeting Talk: Product Questions Targeting Tools: Leptin-SAP (Cat. #IT-47) …

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Targeting Tools: Leptin-SAP

Leptin-SAP (Cat. #IT-47) is a conjugate between recombinant mouse leptin and saporin. Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and …

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Targeting Topics 10q1

Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats Wilson RE, Coons KD, Sengelaub DR Neurosci Lett 465(2):123-127, 2009. Previous work demonstrated a protective effect from testosterone in a motoneuron nerve injury model for male rats. This work investigated whether testosterone has the same effect in females. Female rats …

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Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats

Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region …

Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats Read More »