10q1

Targeting Trends Newsletter 10q1

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights 2009 SfN Poster Award Winner (page 2) Lot-to-lot variation; Saporin activity (page 5) Teaser Winners (page 4) Leptin-SAP (page 7) New Distributor (page 7) Complete …

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Targeting Tools: Leptin-SAP

Leptin-SAP (Cat. #IT-47) is a conjugate between recombinant mouse leptin and saporin. Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and …

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Targeting Topics 10q1

Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats Wilson RE, Coons KD, Sengelaub DR Neurosci Lett 465(2):123-127, 2009. Previous work demonstrated a protective effect from testosterone in a motoneuron nerve injury model for male rats. This work investigated whether testosterone has the same effect in females. Female rats …

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Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats

Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region …

Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats Read More »