Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights 2009 SfN Poster Award Winner (page 2) Lot-to-lot variation; Saporin activity (page 5) Teaser Winners (page 4) Leptin-SAP (page 7) New Distributor (page 7) Complete …
Leptin-SAP (Cat. #IT-47) is a conjugate between recombinant mouse leptin and saporin. Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and …
We have a question about two 192-IgG-SAP (Cat. #IT-01) lots. According to your data sheet there is an approximate 4-fold difference in ED50 between your new lot and old lot. We also observed a clear difference in behavior between animals dosed with the new batch and the old one. It is thus obvious that the …
Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats Wilson RE, Coons KD, Sengelaub DR Neurosci Lett 465(2):123-127, 2009. Previous work demonstrated a protective effect from testosterone in a motoneuron nerve injury model for male rats. This work investigated whether testosterone has the same effect in females. Female rats …
Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region …