gPIG-ZAP uses your guinea pig primary antibody to target and eliminate cells. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-guinea pig IgG) to “piggyback” onto YOUR guinea pig primary antibody. gPIG-ZAP can be utilized for screening guinea pig IgG antibodies for internalization and/or their suitability to make potent immunotoxins. When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.
gPIG-ZAP is a chemical conjugate of affinity-purified goat anti-guinea pig IgG and the ribosome-inactivating protein, saporin. gPIG-ZAP uses your guinea pig affinity-purified polyclonal antibody to target and eliminate cells. This secondary conjugate is used to evaluate the potential of a primary antibody to internalize.
gPIG-ZAP is available individually (Cat. #IT-64) or as a kit (Cat. #KIT-64) which includes gPIG-ZAP, Saporin (Cat. #PR-01), Goat IgG-SAP (Cat. #IT-19) and reagents for developing a cytotoxicity assay.