a tool for use as control for human IgG-containing immunolesioning agents; non-targeted via pre-immune human IgG antibody conjugated to saporin
Human IgG-SAP serves as a control for the human IgG-containing immunolesioning agents. Conjugates utilizing human or humanized antibodies will benefit from using Human IgG-SAP as it is manufactured in an identical manner as other targeted conjugates, to give a definitive baseline for comparison.
Human IgG-SAP serves as a control for human IgG-containing immunolesioning agents.
keywords: saporin, control, IgG, human, whole
You must be logged in to post a review.
Mab-ZAP: A tool for evaluating antibody efficacy for use in an immunotoxin.
Kohls MD, Lappi DA (2000) Mab-ZAP: A tool for evaluating antibody efficacy for use in an immunotoxin. BioTechniques 28(1):162-165. doi: 10.2144/00281pf01
Summary: Immunotoxins are useful tools for elimination of specific cell populations in vitro and in vivo for research and therapeutic applications. One of the factors limiting the use of immunotoxins is the selection of an appropriate antibody. Advanced Targeting Systems has created a reagent that allows researchers to select antibodies with the desired characteristics before an immuntoxin is made, purified, and assayed. Using a goat anti-murine IgG coupled to the ribosome-inactivating protein saporin, researchers can screen hundreds of antibodies in a time and cost-effective manner.
Related Products: Mab-ZAP (Cat. #IT-04), Rab-ZAP (Cat. #IT-05), Hum-ZAP (Cat. #IT-22), Rat-ZAP (Cat. #IT-26), Anti-M-ZAP (Cat. #IT-30), Goat-ZAP (Cat. #IT-36)
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2022) Saporin as a commercial reagent: its uses and unexpected impacts in the biological sciences-tools from the plant kingdom. Toxins (Basel) 14(3):184. doi: 10.3390/toxins14030184
Targeting Tools: Control Immunotoxins
Control Conjugates – The Perfect Companion for Targeted Toxins
Reviews
There are no reviews yet.