CD22 is characterized as a doublet of 130/140 kDa and is expressed on the surface of normal human B-cells and some neoplastic B-cell lines and tumors. CD22 has also been further divided into four different epitope groups, A, B, C, and D, which represent groups of determinants situated on different portions of the CD22 molecule. Anti-CD22-SAP recognizes and specifically eliminates cells that possess the group-A epitope of the human B-cell antigen, CD22. Anti-CD22 immunotoxins have been used to study precursor-B cell acute lymphoblastic leukemia.
Anti-CD22-SAP is a chemical conjugate of a mouse monoclonal antibody to Human CD22 and the ribosome-inactivating protein, saporin. It specifically eliminates cells that express the group-A epitope of the human B-cell antigen, CD22.
Anti-CD22-SAP is available individually (Cat. #IT-37) or as a kit (Cat. #KIT-37) which includes Anti-CD22-SAP and Mouse IgG-SAP (Cat. #IT-18).
keywords: CD22, human B cells, UV22-2, B-cell, Anti-CD22, acute, lymphoblastic, leukemia, saporin, targeting, immunotoxin
The epitope specificity and tissue reactivity of four murine monoclonal anti-CD22 antibodies.
Li JL, Shen GL, Ghetie MA, May RD, Till M, Ghetie V, Uhr JW, Janossy G, Thorpe PE, Amlot P, Vitetta ES (1989) The epitope specificity and tissue reactivity of four murine monoclonal anti-CD22 antibodies. Cell Immunol 118(1):85-99. doi: 10.1016/0008-8749(89)90359-6 PMID: 2463099
Related Products: CD22 Mouse Monoclonal (Cat. #AB-36), Anti-CD22-SAP human (Cat. #IT-37)
Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas.
Shen GL, Li JL, Ghetie MA, Ghetie V, May RD, Till M, Brown AN, Relf M, Knowles P, Uhr JW, Janossy G, Amlot P, Vitetta ES, Thorpe PE (1988) Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas. Int J Cancer 42(5):792-797. doi: 10.1002/ijc.2910420527 PMID: 3263328
Related Products: CD22 Mouse Monoclonal (Cat. #AB-36), Anti-CD22-SAP human (Cat. #IT-37)
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