CD22 is characterized as a doublet of 130/140 kDa and is expressed on the surface of normal human B-cells and some neoplastic B-cell lines and tumors. CD22 has also been further divided into four different epitope groups, A, B, C, and D, which represent groups of determinants situated on different portions of the CD22 molecule.
This IgG1 k antibody recognizes the group-A epitope of the human B-cell antigen, CD22. Clone UV22-2 reacts exclusively with cells of normal human B-cell lineage. Daudi cells from a Burkitt’s lymphoma were used as immunogen. This antibody is routinely tested by flow cytometry.
Applications include flow cytometry, indirect immuofluorescence, radiolabeling and immunoprecipitation, radioimmunoassay, immunoperoxidase staining (human tissues), and targeting.
keywords: CD22, human B cells, UV22-2, B-cell, Anti-CD22