GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving gamma-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, sleep disorders, neuropathic pain, and attention deficit disorders. GAT1-SAP recognizes cells that express the GABA-1 transporter, GAT-1 in rat. The peptide used as an antigen has 100% sequence homology between rat, human, mouse, and bovine GAT-1.
GAT1-SAP is a chemical conjugate of an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing GAT-1.
GAT1-SAP is available individually (Cat. #IT-32) or as a kit (Cat. #KIT-32) which includes GAT1-SAP and Rabbit IgG-SAP (Cat. #IT-35).
GAT-1 Products:
GAT-1 Rabbit Polyclonal, affinity-purified (Cat. #AB-N37) | biotin-labeled (Cat. #AB-N37-BT) | Alexa488-labeled (Cat. #AB-N37-FLA)
keywords: GAT-1, GABA-1 transporter, gaba, gamma-aminobutyric acid, γ-aminobutyric acid, Anti-GAT-1, Anti-GAT1, Anti-GABA-1 transporter, Anti-gamma-aminobutyric acid-1 transporter, Anti-γ-aminobutyric acid-1 transporter, saporin, GABAergic neurons
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