GAT1-SAP [IT-32, KIT-32]

a tool for eliminating cells that express GABA-1 transporter in mutiple species; targeted via an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence, eliminated via saporin

SKU: IT-32 Category: Antibody Type: affinity-purified, Polyclonal | Host: Rabbit | Reactivity: rat | Conjugate: saporin | Usage: eliminates cells |
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GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving gamma-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, sleep disorders, neuropathic pain, and attention deficit disorders. GAT1-SAP recognizes cells that express the GABA-1 transporter, GAT-1 in rat. The peptide used as an antigen has 100% sequence homology between rat, human, mouse, and bovine GAT-1.

GAT1-SAP is a chemical conjugate of an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing GAT-1.

GAT1-SAP is available individually (Cat. #IT-32) or as a kit (Cat. #KIT-32) which includes GAT1-SAP and Rabbit IgG-SAP (Cat. #IT-35).