GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving gamma-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, sleep disorders, neuropathic pain, and attention deficit disorders. GAT1-SAP recognizes cells that express the GABA-1 transporter, GAT-1 in rat. The peptide used as an antigen has 100% sequence homology between rat, human, mouse, and bovine GAT-1.
GAT1-SAP is a chemical conjugate of an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing GAT-1.