Interleukin-2 receptors are located on the surface of T-cells and function in clonal expansion of the activated T-cell. The monoclonal CD-25 antibody inhibits the proliferation of Interleukin-2 (CD25)-dependent murine cell lines. It blocks the murine T-cell receptor for IL-2 by binding to the alpha-chain of IL-2 receptors. This antibody has also been shown to inhibit IL-2 binding to both low and high affinity IL-2 receptors. Anti-CD25-SAP specifically eliminates cells expressing mouse CD25 and is potently cytotoxic to mouse activated T-cells. Anti-CD25 immunotoxins have been shown to remove activated T lymphocytes in culture, and can be used to understand the role of this population in its various processes in the immune system. It has also been suggested for clinical use in the treatment of T-cell leukemias and lymphomas.
Anti-CD25-SAP is a chemical conjugate of a monoclonal antibody to mouse CD25 (Tac, IL-2 receptor) and the ribosome-inactivating protein, saporin. It specifically eliminates cells that express the murine Interleukin-2 (IL-2) receptor.
To eliminate CD25-expressing cells in human, use Anti-CD25-SAP human (Cat. #IT-24).