Anti-CD25-SAP mouse [IT-29, KIT-29]

a tool for eliminating cells that express Interleukin-2 (IL-2) receptor in mouse; targeted via a monoclonal antibody to mouse CD25 (Tac, IL-2 receptor), eliminated via saporin

SKU: IT-29 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Antibody Type: Monoclonal | Host: rat | Reactivity: mouse | Conjugate: saporin | Usage: eliminates cells, retrograde transport |

Interleukin-2 receptors are located on the surface of T-cells and function in clonal expansion of the activated T-cell. The monoclonal CD-25 antibody inhibits the proliferation of Interleukin-2 (CD25)-dependent murine cell lines. It blocks the murine T-cell receptor for IL-2 by binding to the alpha-chain of IL-2 receptors. This antibody has also been shown to inhibit IL-2 binding to both low and high affinity IL-2 receptors. Anti-CD25-SAP specifically eliminates cells expressing mouse CD25 and is potently cytotoxic to mouse activated T-cells. Anti-CD25 immunotoxins have been shown to remove activated T lymphocytes in culture, and can be used to understand the role of this population in its various processes in the immune system. It has also been suggested for clinical use in the treatment of T-cell leukemias and lymphomas.

Anti-CD25-SAP is a chemical conjugate of a monoclonal antibody to mouse CD25 (Tac, IL-2 receptor) and the ribosome-inactivating protein, saporin. It specifically eliminates cells that express the murine Interleukin-2 (IL-2) receptor.

To eliminate CD25-expressing cells in human, use Anti-CD25-SAP human (Cat. #IT-24).

Anti-CD25-SAP is available individually (Cat. #IT-29) or as a kit (Cat. #KIT-29) which includes Anti-CD25-SAP and Rat IgG-SAP (Cat. #IT-17).

keywords: Saporin, CD25, Anti-CD25, Tac, IL-2, interleukin-2, T-cell, receptor, T-lymphocytes, leukemia, lymphoma


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View Data Sheet

Rat IgG-SAP (Cat. #IT-17)

CD25 Products:

CD25 Mouse Monoclonal (Cat. #AB-18) | biotin-labeled (Cat. #AB-18-BT) | Alexa488-labeled (Cat. #AB-18-FLA)

CD25 Rat Monoclonal (Cat. #AB-19) | biotin-labeled (Cat. #AB-19-BT) | Alexa488-labeled (Cat. #AB-19-FLA)

Targeted Toxins: Anti-CD25-SAP human (Cat. #IT-24) | Anti-CD25-SAP mouse (Cat. #IT-29)

Cytotoxicity Assay for Targeted Toxins in vitro

Concentration Calculation Explained: Convert molarity to mg/ml and mg/ml to molarity

Preparing and Interpreting Cytotoxicity Data in vitro

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