The CD25 monoclonal antibody inhibits the proliferation of interleukin-2 (IL-2)-dependent human continuous T-cell lines. It blocks the human T-cell receptor for IL-2 by binding to the alpha-chain of the IL-2 receptor. Anti-CD25-SAP recognizes and specifically eliminates cells expressing human CD25. Anti-CD25 immunotoxins have been shown to remove activated T lymphocytes in culture, and can be used to understand the role of this population in its various processes in the immune system. It has also been suggested for clinical use in the treatment of T-cell leukemias and lymphomas.
Anti-CD25-SAP is a chemical conjugate of a monoclonal antibody to human CD25 (Tac, IL-2 receptor, Cat. #AB-18) and the ribosome-inactivating protein, saporin. It specifically eliminates cells that express the human Interleukin-2 (IL-2) receptor.
To eliminate CD25-expressing cells in mouse, use Anti-CD25-SAP mouse (Cat. #IT-29).