CD40 is a costimulatory receptor expressed on antigen-presenting cells, including B cells, and plays a critical role in their activation and functional maturation. B cell development requires multiple signals, including antigen presentation via MHC, cytokine exposure (such as IL-2, IL-4, and IL-5), and receptor-mediated costimulation. Interaction between CD40 and its ligand CD154 (CD40L), which is expressed on activated T helper cells, promotes B cell maturation and the acquisition of downstream effector functions.
This targeted toxin recognizes cells that express the CD40 receptor in humans. Anti-CD40-SAP is a direct conjugate between mouse monoclonal antibody to human CD40 (clone 626) and the ribosome-inactivating protein, saporin.
The following control is included for validating the specificity of the beta conjugate: Mouse IgG-SAP (Cat. #IT-18)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.