Notch3 is a transmembrane protein belonging to the Notch superfamily, characterized by multiple extracellular EGF-like repeats and conserved Notch domains. The Notch signaling pathway is a highly conserved mechanism of cell-to-cell communication that governs a range of developmental processes, including lateral inhibition during embryogenesis. Notch3 has drawn attention as a potential therapeutic target, as it is overexpressed in several cancers and may contribute to tumor progression.
This targeted toxin recognizes cells that express the Notch3 receptor in mouse. Anti-Notch3-SAP is a direct conjugate between mouse monoclonal antibody to human Notch3 (clone
7G7-B10-H3) and the ribosome-inactivating protein, saporin.
The following control is included for validating the specificity of the beta conjugate: Mouse IgG-SAP (Cat. #IT-18)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.