The Prolactin receptor (PRLR) is a membrane-bound protein and is a type I cytokine receptor. Ligands for PRLR include prolactin (PRL), placental growth hormone, and human placental lactogen. PRLR is found to be expressed in several tissues that include mammary glands, pituitary glands, adrenal glands, uterus, heart, liver, kidney, brain and immune cells. PRLR is involved in the lobuloalveolar development of mammary glands during pregnancy and lactation. Studies have shown that PRLR is a potential target for breast cancer research and is found to be rapidly internalized and traffics efficiently to lysosomes, where it is degraded.
Prolactin-SAP is a bonded toxin between a biotinylated recombinant mouse prolactin and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin.
Prolactin-SAP eliminates cells expressing mouse prolactin receptor. All other cells are left untouched.
The following control is included for validating the specificity of the beta conjugate: Blank-Streptavidin-SAP (Cat. #IT-27B)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.
keywords: prolactin receptor, PRLR, lactogen, targeted conjugate, streptavidin, saporin