Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery. The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized). The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface. The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death. Cells that do not have the cell surface marker are not affected.
CSF-1 (Colony Stimulating Factor 1) binds to the CSF-1 receptor which is primarily found on the surface of certain immune cells, such as monocytes, macrophages, and dendritic cells.
This targeted toxin recognizes cells that express the CSF-1 receptor in horse, human, and mouse. Anti-CSF-1-SAP is a chemical conjugate of the antibody to CSF-1 and the ribosome-inactivating protein, saporin. Anti-CSF-1-SAP specifically eliminates cells that express the CSF-1 receptor. All other cells are left untouched.
The following control is included for validating the specificity of the beta conjugate: Rabbit IgG-SAP (Cat. #IT-35).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.