The metabotropic glutamate receptors (mGluR) play diverse roles in brain function and pathology. Eight mGluR’s have been cloned thus far, they have been separated into three subgroups according to sequence homology, intracellular second messengers, and ligand selectivities. mGluR2 and mGluR3 are the mGluR’s that react most potently with trans-1-aminocyclopentane-1,3-dicarboxlyate.
This antibody recognizes the metabotropic glutamate receptor 2, but not metabotropic glutamate receptor 3, in rat and mouse. The antibody was made against a GST-fusion with a 47-amino acid sequence against the N-terminal portion of mGluR2.
Applications include immunoblotting, immunohistochemistry, immunostaining, and immunofluorescence.