The metabotropic glutamate receptors (mGluR) play diverse roles in brain function and pathology. Eight mGluR’s have been cloned thus far, they have been separated into three subgroups according to sequence homology, intracellular second messengers, and ligand selectivities. mGluR2 and mGluR3 are the mGluR’s that react most potently with trans-1-aminocyclopentane-1,3-dicarboxlyate.
This antibody recognizes the metabotropic glutamate receptor 2, but not metabotropic glutamate receptor 3, in rat and mouse. The antibody was made against a GST-fusion with a 47-amino acid sequence against the N-terminal portion of mGluR2.
Applications include immunoblotting, immunohistochemistry, immunostaining, and immunofluorescence.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R (2019) Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J 33(12):13734-13746. doi: 10.1096/fj.201901543R PMID: 31585509
Kamath SP, Chen AI (2018) Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar Purkinje cells. Mol Neurobiol 56:4102–4119. doi: 10.1007/s12035-018-1363-7 PMID: 30276662
Objective: To investigate the roles of Mef2c in cerebellar Purkinje cells during the first three weeks of postnatal development.
Summary: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Results reveal the specific expression and functional relevance of Mef2c in developing Purkinje cells and offer insight to how disruption of the expression of Mef2c in a GABAergic neuronal subtype may lead to pathogenesis of cerebellar-associated disorders.
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