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Glutamatergic neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice.

Krajewski-Hall SJ, Miranda Dos Santos F, McMullen NT, Blackmore EM, Rance NE (2019) Glutamatergic neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice. Endocrinology 160(4):803-816. doi: 10.1210/en.2018-00934 Objective: To characterize the thermoregulatory role of MnPO NK3R neurons in female mice. Summary: Study suggests that KNDy neurons modulate thermosensory pathways […]

Glutamatergic neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice. Read More »

Rodent models: Autism and fragile x syndrome

Walker BR, Klueger K (2006) Rodent models: Autism and fragile x syndrome. Neuroscience 2006 Abstracts 764.6. Society for Neuroscience, Atlanta, GA. Summary: While the exact etiology of autism is not known, autism spectrum disorders (ASD) are most commonly characterized by behavioral deficits in social interaction and communication, obsessional mannerisms, behavioral inflexibility, impairments in planning, attention,

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Saporin Safety

Over the years, ATS has frequently been asked about Saporin’s safety for use in the lab as well as when used clinically. Residual awareness of alternate Ribosome-Inactivating Proteins (RIPs) and ‘toxins’ such as Ricin have caused some researchers new to the use of RIPs to question the belief that Saporin is safe. Unlike Type 2 RIPs

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Safety Studies Begin

SP SAP Drug Development /

Early last month (March 2001), Advanced Targeting Systems (ATS) received funding from the National Institute of Mental Health (NIMH) to begin toxicology/safety studies of Substance P-Saporin (SP-SAP), a potential therapeutic for the treatment of chronic pain. The studies will be completed under the direction of three scientists who are experts in their respective fields. Dr.

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Substance P-saporin lesions of NK1-receptor expressing neurons in the medullary raphe reduce central chemoreception in sleep and wakefulness

Nattie EE, Li A (2003) Substance P-saporin lesions of NK1-receptor expressing neurons in the medullary raphe reduce central chemoreception in sleep and wakefulness. Neuroscience 2003 Abstracts 826.7. Society for Neuroscience, New Orleans, LA. Summary: Breathing, especially in sleep, depends on a CO2-related drive that comes from central chemoreceptors. Many brainstem chemoreceptor sites contain NK1-receptor expressing

Substance P-saporin lesions of NK1-receptor expressing neurons in the medullary raphe reduce central chemoreception in sleep and wakefulness Read More »

TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets.

Lowe D, Bivens C, Mobley A, Herrera C, McCormick A, Wichner T, Sabnani M, Wood L, Weidanz J (2017) TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets. MAbs 9:603-614. doi: 10.1080/19420862.2017.1302630 Objective: To analyze the killing potential of TCR-like ADCs. Summary: Data comprise proof-of-principle results that TCR-like ADCs mediate potent

TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets. Read More »

Cover Article: Basomedial Hypothalamic Injections of Neuropeptide Y Conjugated to Saporin Selectively Disrupt Hypothalamic Controls of Food Intake

News Article /

This article is a summary of data presented in reference #1. Figures 1-4 are taken from that article. This work was funded by NS045520 and DK40498 to S. Ritter. Neuropeptide Y (NPY) conjugated to saporin (SAP), a ribosomal toxin, is a compound designed to selectively target and lesion NPY receptor-expressing cells. We conducted competitive binding

Cover Article: Basomedial Hypothalamic Injections of Neuropeptide Y Conjugated to Saporin Selectively Disrupt Hypothalamic Controls of Food Intake Read More »

Light- and food-entrained circadian rhythms in rats with neurotoxic lesions of hypocretin cells.

Mistlberger RE, Antle MC, Jones M, Kilduff TS (2001) Light- and food-entrained circadian rhythms in rats with neurotoxic lesions of hypocretin cells. Neuroscience 2001 Abstracts 410.8. Society for Neuroscience, San Diego, CA. Summary: The hypocretins (Hcrt1 & 2) are lateral hypothalamic (LH) neuropeptides implicated in the regulation of feeding and sleep-wake states. Hcrt lesions attenuate

Light- and food-entrained circadian rhythms in rats with neurotoxic lesions of hypocretin cells. Read More »

Targeting Tools: NK3-SAP

News Tools /

An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NK3-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several

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Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

Fang J, Sia J, Soto J, Wang P, Li LK, Hsueh YY, Sun R, Faull KF, Tidball JG, Li S (2021) Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng 5(8):864-879. doi: 10.1038/s41551-021-00696-y PMID: 33737730 Objective: To show that myogenic stem cells expanded

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro Read More »

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