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SUVN-G3031, H3 receptor inverse agonist produces wake promoting activity in rats with hypocretin-2-saporin lesions of the lateral hypothalamus

Daripelli S, Bhayrapuneni G, Tirumalesetty C, Benade V, Subramanian R, Petlu S, Praveena N, Jayarajan P, Shinde A, Badange R, Bhatta V, Nirogi R (2018) SUVN-G3031, H3 receptor inverse agonist produces wake promoting activity in rats with hypocretin-2-saporin lesions of the lateral hypothalamus. Neuroscience 2018 Abstracts 679.23 / VV4. Society for Neuroscience, San Diego, CA. […]

SUVN-G3031, H3 receptor inverse agonist produces wake promoting activity in rats with hypocretin-2-saporin lesions of the lateral hypothalamus Read More »

Effect of selective cholinergic lesion of the septohippocampal pathway on the carbachol stimulated GTPγS binding in rat hippocampus

Pokala VN, Witt-Enderby PA, Johnson DA (2003) Effect of selective cholinergic lesion of the septohippocampal pathway on the carbachol stimulated GTPγS binding in rat hippocampus. Neuroscience 2003 Abstracts 799.7. Society for Neuroscience, New Orleans, LA. Summary: Previously we have shown that selective lesion of the septohippocampal cholinergic pathway in the rat resulted in a significant

Effect of selective cholinergic lesion of the septohippocampal pathway on the carbachol stimulated GTPγS binding in rat hippocampus Read More »

Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius.

Fu C, Xue J, Wang R, Chen J, Ma L, Liu Y, Wang X, Guo F, Zhang Y, Zhang X, Wang S (2017) Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius. J Physiol 595:4973-4989.. doi: 10.1113/JP274437 Objective: To investigate whether paired-like homeobox 2b  (Phox2b)-expressing NTS neurons are recruited in

Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius. Read More »

Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways.

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Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well

Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways. Read More »

Dose-dependent effects of intrathecal substance P-saporin and SSP-saporin.

Wiley RG, Kline IV RH, Lappi DA (2001) Dose-dependent effects of intrathecal substance P-saporin and SSP-saporin. Neuroscience 2001 Abstracts 281.11. Society for Neuroscience, San Diego, CA. Summary: Selective destruction of lamina I dorsal horn neurons expressing the neurokinin-1 receptor (NK-1R) can attenuate responses to capsaicin injection and thermal hyperalgesia/mechanical allodynia in models of inflammatory, persistent

Dose-dependent effects of intrathecal substance P-saporin and SSP-saporin. Read More »

Targeting Tools: NK3-SAP

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An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NK3-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several

Targeting Tools: NK3-SAP Read More »

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

Fang J, Sia J, Soto J, Wang P, Li LK, Hsueh YY, Sun R, Faull KF, Tidball JG, Li S (2021) Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng 5(8):864-879. doi: 10.1038/s41551-021-00696-y PMID: 33737730 Objective: To show that myogenic stem cells expanded

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro Read More »

Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder.

Lim I, Mitsui R, Kameda M, Sellers DJ, Chess‐Williams R, Hashitani H (2021) Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Neurourol Urodyn 40:102-111. doi: 10.1002/nau.24548 PMID: 33074588 Objective: To explore contractile actions of angiotensin II (AT2) on the muscularis mucosae (MM) of the bladder.

Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Read More »

Neurovascular Coupling and Brain Imaging

Targeting Topics /

Lecrux et al. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. Journal of Neuroscience (2017), 1784-16. PMID: 28069927 Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to “neurovascular coupling” (NVC). It is unknown whether

Neurovascular Coupling and Brain Imaging Read More »

Selective cholinergic and GABAergic lesions of the medial septum slows acquisition of the classically conditioned eyeblink response in rats.

Roland JJ, Janke KL, Gluck MA, Beck KD, Pang KCH, Servatius RJ (2009) Selective cholinergic and GABAergic lesions of the medial septum slows acquisition of the classically conditioned eyeblink response in rats. Neuroscience 2009 Abstracts 283.6/EE135. Society for Neuroscience, Chicago, IL. Summary: Both human and animal studies have demonstrated that the hippocampus is not essential

Selective cholinergic and GABAergic lesions of the medial septum slows acquisition of the classically conditioned eyeblink response in rats. Read More »

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