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2021 Targeting Trends Review
Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats.
Dezawa S, Nagasaka K, Watanabe Y, Takashima I (2021) Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Exp Neurol 335:113493. doi: 10.1016/j.expneurol.2020.113493
Summary: The authors used 192-IgG-SAP to produce a selective cholinergic lesion in the nucleus basalis of Meynert (NBM) of rats and investigated whether the NBM lesion led to tactile hypersensitivity in the forepaw. Results suggest that neuronal loss in the NBM diminishes acetylcholine actions in the S1, thereby enhancing the cortical representation of sensory stimuli, which may in turn lead to behavioral hypersensitivity.
Usage: The lesion group received injection of 0.3 μL of 192-IgG-SAP into the left nucleus basalis of Meynert (NBM).
Related Products: 192-IgG-SAP (Cat. #IT-01)
Plant-virus infection inhibitors: The great potential of Caryophyllales species
Duarte L, Alexandre M, Chaves A, Santos D, deSouza A, Bernacci L (2021) Plant-virus infection inhibitors: The great potential of Caryophyllales species. Physiol Mol Plant Pathol 113:101597. doi: 10.1016/j.pmpp.2020.101597
Related Products: Saporin (Cat. #PR-01)
Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder.
Lim I, Mitsui R, Kameda M, Sellers DJ, Chess‐Williams R, Hashitani H (2021) Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Neurourol Urodyn 40:102-111. doi: 10.1002/nau.24548 PMID: 33074588
Objective: To explore contractile actions of angiotensin II (AT2) on the muscularis mucosae (MM) of the bladder.
Summary: The MM appears to have great sensitivity to AT2, suggesting that MM may be the predominant target of contractile actions induced by AT2 in the bladder.
Usage: Induction of contractions with Anti-AT2R (1 nM – 1 µM). Immunofluorescence (10-100 pM).
Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency.
Castiello MC, Bosticardo M, Sacchetti N, Calzoni E, Fontana E, Yamazaki Y, Draghici E, Corsino C, Bortolomai I, Sereni L, Yu HH, Uva P, Palchaudhuri R, Scadden DT, Villa A, Notarangelo LD (2021) Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. J Allergy Clin Immunol 147(1):309-320.e6. doi: 10.1016/j.jaci.2020.04.033
Objective: To improve multi-lineage engraftment using non-genotoxic conditioning with Anti-CD45-Saporin.
Summary: Conditioning with Anti-CD45 antibody-drug conjugates may represent a novel and safe conditioning regimen for patients with RAG deficiency and other inborn errors of immunity.
Usage: Intravenous injection of Anti-CD45-SAP (3 mg/kg).
Related Products: Streptavidin-ZAP (Cat. #IT-27)
Aberrant functional connectivity of basal forebrain subregions with cholinergic system in short-term and chronic insomnia disorder
Ma X, Fu S, Yin Y, Wu Y, Wang T, Xu G, Liu M, Xu Y, Tian J, Jiang G (2021) Aberrant functional connectivity of basal forebrain subregions with cholinergic system in short-term and chronic insomnia disorder. J Affect Disord 278:481-487. doi: 10.1016/j.jad.2020.09.103
Summary: Previous animal studies have identified the cholinergic basal forebrain (CBF) as a crucial structure in sleep-wake cycle modulation and lesion or inactivation of the BF has been found to increase delta electroencephalogram activity, disturb behavioral arousal, and reduce sleep. They reference Kaur et al. using 192-IgG-SAP to lesion the CBF to examine the role of these neurons in sleep behavior.
Related Products: 192-IgG-SAP (Cat. #IT-01)
From obesity to hippocampal neurodegeneration: Pathogenesis and non-pharmacological interventions
Lee TH, Yau SY (2021) From obesity to hippocampal neurodegeneration: Pathogenesis and non-pharmacological interventions. Int J Mol Sci 22(1):201. doi: 10.3390/ijms22010201
Summary: This review provides insights into how chronic metabolic disorders, like obesity, could impair brain health and cognitive functions in later life. The authors reference the use of CCK-SAP into the nodose ganglia to impair spatial memory and contextual episodic memory.
Related Products: CCK-SAP (Cat. #IT-31)
Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery
Pazo M, Salluce G, Lostalé-Seijo I, Juanes M, Gonzalez F, Garcia-Fandiño R, Montenegro J (2021) Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery. RSC Chem Biol 2:503-512. doi: 10.1039/D0CB00103A
Related Products: Saporin (Cat. #PR-01)
Characterizing the neural substrate of reward with the use of specific brain lesions
Cromwell HC (2021) Characterizing the neural substrate of reward with the use of specific brain lesions. Fakhoury M (Ed.): The Brain Reward System. Neuromethods. 165. Humana, New York, NY doi: 10.1007/978-1-0716-1146-3_3
Summary: This review is focused on experimental lesions and work using the rodent model examining the neural substrates of reward processing. Saporin is listed as a neurotoxin used to target selective neuronal populations with success.
Related Products: 192-IgG-SAP (Cat. #IT-01)