Kaur S, Junek A, Black MA, Semba K (2008) Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in rats. J Neurosci 28:491-504. doi: 10.1523/JNEUROSCI.1585-07.2008
Objective: To examine the role of this area of the brain in several facets of sleep behavior.
Summary: The results suggest that cholinergic neurons and non-cholinergic neurons in the basal forebrain play different, but important roles in non-rapid eye movement sleep and EEG delta power after sleep loss. Non-cholinergic basal forebrain neurons inhibit delta waves, whereas cholinergic neurons promote wakefulness.
Usage: The caudal basal forebrain of rats was lesioned with 0.26-µg bilateral injections of 192-IgG-SAP.
Related Products: 192-IgG-SAP (Cat. #IT-01)