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2020 Targeting Trends Review
ALPPL2 is a highly specific and targetable tumor cell surface antigen
Su Y, Zhang X, Bidlingmaier S, Behrens CR, Lee NK, Liu B (2020) ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res 80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418 PMID: 32868383
Objective: To evaluate therapeutic potential of ALPPL2 targeting.
Summary: Exquisite tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against mesothelioma.
Usage: Biotinylated M25 IgG1 and Streptavidin-ZAP were mixed at a molar ratio of 1:1.
Related Products: Streptavidin-ZAP (Cat. #IT-27)
An age- and sex-dependent role of catecholaminergic neurons in the control of breathing and hypoxic chemoreflex during postnatal development.
Patrone LGA, Capalbo AC, Marques DA, Bícego KC, Gargaglioni LH (2020) An age- and sex-dependent role of catecholaminergic neurons in the control of breathing and hypoxic chemoreflex during postnatal development. Brain Res 1726:146508. doi: 10.1016/j.brainres.2019.146508
Objective: To discover the role of brainstem catecholaminergic (CA) neurons in the hypoxic ventilatory response (HVR).
Summary: Brainstem CA neurons modulate the HVR during the postnatal phase, and possibly thermoregulation during hypoxia.
Usage: Evaluation of brainstem CA neurons in the HVR during postnatal development in male and female rats through specific cell depletion with Anti-DBH-SAP (420 ng/nL) injected in the fourth ventricle.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function
Abbasloo E, Najafipour H, Vakili A (2020) Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function. Clin Exp Pharmacol Physiol 47:393-402. doi: 10.1111/1440-1681.13195 PMID: 31630435
Objective: To determine the effect of chronic pretreatment with apelin, losartan and their combination on ischemia-reperfusion (IR) injury in the isolated perfused rat heart and on the expression of apelin-13 receptor (APJ) and angiotensin type 1 receptor (AT1R) in the myocardium.
Summary: Chronic pretreatment with apelin along with AT1R antagonist had more protective effects against IR injury.
Usage: 1:10000
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience
Herman JP (2020) Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience. Chen A (Ed.): Stress Resilience 291-309. Academic Press doi: 10.1016/B978-0-12-813983-7.00019-7
Summary: Review. Immunolesion of paraventricular nucleus (PVN)-projecting norepinephrine (NE) neurons with Anti-DBH-SAP attenuates acute stress reactivity (interestingly, to restraint), but it does not inhibit somatic or HPA axis responses to stress in any simple way (Flak et al.). PVN-projecting NE neurons appear to be responsible for acute responses to systemic stressors, but they do not appear to be important in mediating effects of chronic stress (Ritter et al.).
Usage: Flak et al. injected 8.82 ng of Anti-DBH-SAP into the PVN. Ritter et al. injected 42 ng into the PVN.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
See Also:
- Flak J et al. Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. Eur J Neurosci 39:1903-1911, 2014.
- Ritter S et al. Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144(4):1357-1367, 2003.