Ritter S, Watts AG, Dinh TT, Sanchez-Watts G, Pedrow C (2003) Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144(4):1357-1367. doi: 10.1210/en.2002-221076
Summary: Hindbrain norepinephrine (NE) and epinephrine (E) neurons are important in the distribution of internal sensory signals. Injecting 42 ng of anti-DBH-SAP (Cat. #IT-03) into the paraventricular nucleus of rat hypothalamus, the authors were able to specifically destroy NE and E neurons. This study revealed the contribution of NE/E afferents to hypothalamo-pituitary-adrenal activation during stress and confirmed that NE and E neurons are required for specific stress responses.
Related Products: Anti-DBH-SAP (Cat. #IT-03)