2004 Targeting Trends Review

Lalonde R, Strazielle C (2003) The effects of cerebellar damage on maze learning in animals. Cerebellum 2(4):300-309. doi: 10.1080/14734220310017456

Summary: Traditionally the cerebellum has been associated with motor control, but recent work has suggested that it plays a role in cognitive functions such as spatial learning as well. This study discusses the effects of cerebellar mutations in mice, and OX7-SAP (Cat. #IT-02) lesions in rats on water maze learning models. Results indicate that the cerebellum plays a role in working memory and the procedural aspect of maze learning, as well as being an important element of motor control.

Related Products: OX7-SAP (Cat. #IT-02)

Bizon JL, Han JS, Hudon C, Gallagher M (2003) Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze. Hippocampus 13(6):676-684. doi: 10.1002/hipo.10113

Summary: To investigate the effect of depleted acetylcholine (Ach) levels in the hippocampus on learning strategies that are thought to utilize the hippocampus, the authors lesioned the medial septum/vertical limb of the diagonal band of Broca in rats with two injections of 75 and 50 ng of 192-Saporin (Cat. #IT-01). The unexpected result was that a hippocampal place strategy was promoted in the absence of Ach.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Beninger RJ, Dringenberg HC, Boegman RJ, Jhamandas K (2001) Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: differential roles for corticopetal versus amygdalopetal projections. Neurotox Res 3(1):7-21. doi: 10.1007/BF03033227

Summary: The cholinergic hypothesis states that projections of cholinergic neurons from the nucleus basalis magnocellularis to cortical and amygdalar targets are important in memory. This review discusses the work done on the cholinergic hypothesis using non-specific lesioning agents such as ibotenate and quisqualate, and the specific targeted conjugate 192-Saporin (Cat. #IT-01). The authors conclude that cholinergic targets in both the cortex and amygdala are important for the control of memory.

Related Products: 192-IgG-SAP (Cat. #IT-01)