Beninger RJ, Dringenberg HC, Boegman RJ, Jhamandas K (2001) Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: differential roles for corticopetal versus amygdalopetal projections. Neurotox Res 3(1):7-21. doi: 10.1007/BF03033227
Summary: The cholinergic hypothesis states that projections of cholinergic neurons from the nucleus basalis magnocellularis to cortical and amygdalar targets are important in memory. This review discusses the work done on the cholinergic hypothesis using non-specific lesioning agents such as ibotenate and quisqualate, and the specific targeted conjugate 192-Saporin (Cat. #IT-01). The authors conclude that cholinergic targets in both the cortex and amygdala are important for the control of memory.
Related Products: 192-IgG-SAP (Cat. #IT-01)