Bizon JL, Han JS, Hudon C, Gallagher M (2003) Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze. Hippocampus 13(6):676-684. doi: 10.1002/hipo.10113 PMID: 12962313
Summary: To investigate the effect of depleted acetylcholine (Ach) levels in the hippocampus on learning strategies that are thought to utilize the hippocampus, the authors lesioned the medial septum/vertical limb of the diagonal band of Broca in rats with two injections of 75 and 50 ng of 192-Saporin (Cat. #IT-01). The unexpected result was that a hippocampal place strategy was promoted in the absence of Ach.
Usage: Rats injected with 192-IgG-SAP at 0.506 ug/ul with total volume of 0.3 ul.
Related Products: 192-IgG-SAP (Cat. #IT-01)